ANTIDIABETIC PROPERTY OF AZADIRACHTA INDICA; A MOLECULAR APPROACH

Abstract

Diabetes mellitus (DM) is a metabolic syndrome, in which there is chronic high blood glucose level. Amongst non-communicable diseases (NCD), type II Diabetes Mellitus is not only the most prevalent disease but its global burden is increasing rapidly. If the blood glucose level is not maintained appropriately, there is a high probability of the development of both macro-vascular as well as microvascular compli-cations. Multiple antidiabetic drugs are in line, but they fail to give long-term control of hyperglycemia, on the other hand these drugs have side effects as well. So there is a need to switch to natural products. The herbal extracts like Azadirachta indica (Neem) is well known for its powerful antioxidant, anti-inflammatory, antipyretic, antimicrobial and antidiabetic properties. It causes hypoglycemia and peroxi-dation of lipid metabolites while increasing the enzymatic activities of glutathione perox-idases, catalases and superoxide dismutases to enhance the antioxidation