CLINICOPATHOLOGICAL STUDY OF SOLID PSEUDOPAPILLARY TUMOR OF PANCREAS

Solid Pseudopapillary Tumor of Pancreas

Abstract

Objective: To study the morphological and immunohistochemical features of solid pseudopapillary tumor of
pancreas.
Study Design: Retrospective study.
Place and Duration of Study: Shaukat Khanum Memorial Cancer Hospital and Research Centre from Jun 2016 to Mar 2017.
Material and Methods: Sixty-four patients (n=64) including 61 females and 3 males with pathological diagnosis of solid pseudopapillary tumor were selected from archives of Shaukat Khanum Memorial Cancer Hospital and Research Center for the period of 2000-2017. For the sample selected, their morphological features and immunohistochemical profile were reviewed and analyzed. The morphological features are considered as gold standard for the diagnosis.
Results: The mean age was 33 years (range 8-50 years). Immunohistochemical stains were performed on formalin fixed paraffin embedded section of 55 cases. Pancytokeratin was performed on 8 cases, out of which only 2 cases showed positivity. CD10 was performed on 14 cases, out of which only 12 cases showed positivity. Neuron specific enolase (NSE), CD56, vimentin, progesterone receptor (PR) and β catenin were performed on 8,5,3,13 and 16 cases respectively and showed positivity in majority of cases. Neuroendocrine markers (chromogranin and synaptophysin) were performed on 25 and 6 cases, from which it showed weak positivity in 3 cases. CD99 was performed on 19 cases and showed characteristic dot like staining.
Conclusion: Among the immunohistochemical stains, CD99 had a specific dot like staining pattern and was used as a first line marker in diagnosis.

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