Detection of Cytomegalovirus in Post Hematopoietic Stem Cells Transplant Recipients by Real-Time PCR

Authors

  • Saifullah Khan Niazi Department of Pathology, Armed forces Institute of Pathology/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Nadia Gulzar Department of Pathology, Armed forces Institute of Pathology/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Eijaz Ghani Department of Pathology, Armed forces Institute of Pathology/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • faraz ahmed Department of Pathology, Armed forces Institute of Pathology/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Muhammad Ali Rathore Department of Pathology, Armed forces Institute of Pathology/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Noman Shakoor Department of Pathology, Armed forces Institute of Pathology/National University of Medical Sciences (NUMS) Rawalpindi Pakistan

DOI:

https://doi.org/10.51253/pafmj.v73i5.8812

Keywords:

Cytomegalovirus, Hematopoietic stem cell transplant, Real-time polymerase chain reaction

Abstract

Objective: To evaluate the frequency of Cytomegalovirus in Post Hematopoietic Stem Cell Transplant Recipients by molecular method.

Study Design: Cross-sectional study.

Place and Duration of Study: Virology Department, Armed Forces Institute of Pathology, Rawalpindi Pakistan Jan to Dec
2021.

Methodology: One hundred and twenty-six hematopoietic stem cell transplant (HSCT) recipients were included in this study and were separated into various age groups. All included patients were CMV IgG positive. Real-time polymerase chain
reaction (PCR) was performed on post-HSCT recipients to detect CMV.

Results: Out of 126 post-HSCT recipients, CMV was detected in 80(63%) patients and was not found in 46(36%) patients.
Among positive patients, 60(75%) were males, and 20(15%) were female. Maximum cases of CMV detection in post-HSCT
were found in 23 patients aged 1-10 years.

Conclusion: A high frequency of CMV in post-HSCT recipients was observed in this study. CMV cause major complications in immunocompromised patients, such as in transplant recipients. Prevention of CMV infection is a main part of post-transplant monitoring and management.

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Published

30-10-2023

Issue

Section

Original Articles

How to Cite

1.
Niazi SK, Gulzar N, Ghani E, ahmed faraz, Muhammad Ali Rathore, Shakoor N. Detection of Cytomegalovirus in Post Hematopoietic Stem Cells Transplant Recipients by Real-Time PCR. Pak Armed Forces Med J [Internet]. 2023 Oct. 30 [cited 2024 Dec. 12];73(5):1360-3. Available from: https://pafmj.org/PAFMJ/article/view/8812