To evaluate the association between T1DM in offspring with a positive parental history of diabetes: SHINE

Syed Jamal Raza; Muhammad Ali; Jaida Manzoor; Waqas Imran Khan; Sabahat Amir; Mohsina Noor Ibrahim; Navira Chandio; Danish Shah Tariq; Nabeea Junaid

doi:10.51253/pafmj.v74i4.8756

Authors

Syed Jamal Raza Department of Pediatric, National Institute of Child Health Karachi Pakistan
Muhammad Ali Department of Pediatric, Mayo Hospital Lahore Pakistan
Jaida Manzoor Department of Pediatric, The Children's Hospital University of Child Health Sciences Lahore Pakistan
Waqas Imran Khan Department of Pediatric, Children Hospital Multan Pakistan
Sabahat Amir Department of Pediatric, Khyber Teaching Hospital Peshawar Pakistan
Mohsina Noor Ibrahim Department of Pediatric, National Institute of Child Health Karachi Pakistan
Navira Chandio Department of Medicine, Sanofi Pakistan
Danish Shah Tariq Department of Medicine, Sanofi Pakistan
Nabeea Junaid Department of Medicine, Sanofi Pakistan

DOI:

https://doi.org/10.51253/pafmj.v74i4.8756

Keywords:

Type 1 Diabetes Mellitus, insulin auto-antibodies, parental history, Pakistan

Abstract

STRUCTURED ABSTRACT

Objective: The aim of this study was to measure the association between parental history of diabetes and the odds of an offspring having T1DM.

Study Design: SHINE (NCT03312478) was a national, multi-center, case-control study, with a ratio of 1:2 (case: control).

Place and Duration: The study was conducted at specialized pediatric centers for 10 months.

Patient and Methods: Three hundred and seventy-five (125 cases and 250 controls) participants were enrolled in this study. Individuals aged ≥ 2 years and ≤ 20 years with T1DM and who were on insulin for the last 1 year and positive for one or more islet cell autoantibodies were included in the study. Primary data was collected at the time of enrolment. Participants were then contacted telephonically after 15 days for follow-up.

Results: 58% (n=218) of participants were males (mean age 10.66 [3.4] years; mean HbA1c 7.05 [2.78]). 11% (n=14) of the cases were reported to have a family history of diabetes (T2DM 10.4% [n=13]; T1DM 0.8% [n=1]). Regarding the parental history of diabetes, 8% (n=10) mothers reported having diabetes as compared to 3.2% (n=4) fathers. No statistically significant association (p= 0.83, OR= 0.92, 95% CI: 0.404 -2.077) was observed between parental history of diabetes and the odds of an offspring being T1DM.

Conclusion: The results of the study suggest no association between parental diabetic history and odds of occurrence of T1DM in offspring in a Pakistani cohort.