COMPARISON OF EFFECTS OF PROPOFOL AND DEXMEDETOMIDINE ON PATIENT HEMODYNAMICS DURING CORONARY ARTERY BYPASS GRAFT SURGERY

Abstract

Objective: To compare the effects of dexmedetomidine and propofol on hemodynamics of patients undergoing coronary artery bypass graft surgery (CABG).

Study Design: Comparative cross-sectional study.

Place and Duration of Study: Cardiac Anesthesia department, Army Cardiac Centre, Lahore, from Aug 2020 to Feb 2021.

Methodology: Seventy patients who were selected for open heart surgery were enrolled and divided into two groups (D and P) by lottery method. Group D patients were given intravenous dexmedetomidine and group P patients were given propofol only. Changes in hemodynamics (heart rate, mean arterial pressure) was the outcome variables of study. SPSS-24 was used for data analysis.

Results: The mean arterial pressure of dexmedetomidine group during and after induction of anesthesia at 15 min, 30 min, 45min and 60 min was 73.3 mmHg ± 2.65, 70.5 mmHg ± 3.54, 70.1 mmHg ± 4.52 and 69.5mmHG ± 4.12 respectively. The mean arterial pressure of propofol group during and after induction of anesthesia at 15 min, 30 min, 45 min and 60 min was 82.5mmHg ± 2.86, 77.8 mmHg ± 4.54, 78.9mmHg ± 3.52 and 79.4mmHg ± 4.52, respectively.

Conclusion: Changes in mean arterial pressure and heart rate are relatively low in dexmedetomidine group as compared to propofol group. There was a significant difference in hemodynamic effects of both drugs in patients undergoing CABG.