ROLE OF INTERLEUKIN-6 AND PROCALCITONIN AS INFLAMMATORY BIOMARKERS IN EVALUATING COVID-19 DISEASE SEVERITY ON HRCT CHESTAN EXPERIENCE AT CMH QUETTA

Zeeshan Ayub; Azeema Ahmed; Farah Afzal; Saima Bashir; Hamid Iqbal; Khurram Haq Nawaz

doi:10.51253/pafmj.v71i6.6977

Authors

Zeeshan Ayub Combined Military Hospital Quetta/National University of Medical Sciences (NUMS) Pakistan
Azeema Ahmed Combined Military Hospital Quetta/National University of Medical Sciences (NUMS) Pakistan
Farah Afzal Combined Military Hospital Quetta/National University of Medical Sciences (NUMS) Pakistan
Saima Bashir Combined Military Hospital Quetta/National University of Medical Sciences (NUMS) Pakistan
Hamid Iqbal Combined Military Hospital Quetta/National University of Medical Sciences (NUMS) Pakistan
Khurram Haq Nawaz Combined Military Hospital Quetta/National University of Medical Sciences (NUMS) Pakistan

DOI:

https://doi.org/10.51253/pafmj.v71i6.6977

Keywords:

COVID-19 pneumonia, Interlukin-6, Procalcitonin

Abstract

Objective: To explore the relation of Interleukin-6 and Procalcitonin with COVID-19 severity on high resolution computerized tomogram (HRCT) chest.

Study Design: Randomized Control Trial (NCT04945811).

Place and Duration of study: Pathology Department, Combined Military Hospital Quetta, from April 2020 to May 2021.

Methodology: Serum Interleukin-6 and Procalcitonin of 100 consenting COVID-19 positive patients from April 2020 to May 2021 were assessed at Pathology department Combined Military Hospital Quetta and their levels were correlated with severity of lung involvement on HRCT Chest

Results: Serum Interlukin-6 levels were significantly raised in 97 patients with mean levels of 20.43 ± 19.66 (pg/ml). Serum procalcitonin levels were also significantly raised in 95 patients with mean levels of 0.43 ± 0.24 (ng/ml).

Conclusion: Interlukin-6 and procalcitonin are important biomarkers for diagnosis and predicting severity of COVID-19 pneumonia.