FREQUENCY OF HYPERURICEMIA IN PATIENTS WITH CORONARY ARTERY DISEASE AND ITS ASSOCIATION WITH DISEASE SEVERITY, AGE, GENDER, DIABETES MELLITUS, AND HYPERTENSION

Abstract

Objective: To determine frequency of elevated serum uric acid levels in patients with coronary artery disease, association of hyperuricemia with severity of coronary artery disease, gender, age, hypertension, and diabetes mellitus.

Study Design: Cross-sectional study.

Place and Duration of Study: Internal Medicine department, Combined Military Hospital Multan, from Nov 2015 to May 2016.

Methodology: One hundred and fifty patients with coronary artery disease were selected consecutively and admitted for coronary angiography. Serum uric acid levels were evaluated after eight hours fasting by photometric technique having normal reference range of 3.5-6.7 mg/dL. Coronary angiography was performed and Gensini score computed. To compare mean Gensini score between normouricemic and hyperuricemic population, student’s t-test was applied.

Results: A total of 150 study cases (mean age: 54.4 ± 8.5 years), 101 (67.3%) were male while 49 (32.7%) were female. Diabetes mellitus was present in 43 (28.7%) of cases and hypertension was present in 65 (43.3%). Hyperuricemia was noted in 58 (38.7%) of cases. The mean Gensini score in hyperuricemic patients was significantly higher (40.31 ± 14.64) compared to patients with normal serum uric acid levels (25.02 ± 10.94) (p<0.001). The frequency of hyperuricemia was significantly higher in males, patients ≤60 years of age, and patients with diabetes mellitus (p<0.001, p=0.001 and p=0.001). No significant asso-ciation with hypertension was observed (p=0.314).

Conclusion: Frequency of 38.7% for hyperuricemia was noted in our study among patients with coronary artery disease. Hyperuricemia was significantly associated with higher Gensini score, male gender, younger age, and diabetes mellitus.