FREQUENCY OF PATHOLOGICAL COMPLETE RESPONSE (PCR) IN PATIENTS OF TRIPLE NEGATIVE BREAST CANCER AFTER NEO-ADJUVANT CHEMOTHERAPY

Abstract

Objective: To determine the frequency of patients with complete pathological response (pCR) after neo adjuvant chemotherapy (NACT) in locally advanced triple negative breast cancer.

Study Design: Descriptive cross sectional study.

Place and Duration of Study: Department of Oncology, Hameed Latif Hospital, Lahore, from Aug 2019 to Feb 2020.

Methodology: After taking approval from hospital ethics committee, 100 patients coming through Out-patient department who fulfill the selection criteria were enrolled and written informed consent were taken from them.

Results: A total of 100 fulfilling the inclusion/exclusion criteria were enrolled to study to determine frequency of patients with complete pathological response after neo adjuvant chemotherapy in locally advanced triple negative breast cancer. Age distribution of the patients was done, it shows that out of 100 patients, 38 (38%) were between 18-40 years of age whereas 62 (62%) in were between 41-70 years of age, mean age was calculated as 44.18 ± 9.71 years. The data was stratified for age, stage of disease and eastern cooperative oncology group (ECOG) grade of the patients. When associated with grades of the disease, it was found to be statistically significant (p=0.003).

Conclusion: Hence we concluded that about one third of the patients with neo adjuvant chemotherapy showed complete pathological response.