Diagnostic Accuracy of Barium Enema for the Diagnosis of Hirsch-sprung Disease in Children

Authors

  • Zahid Anwar Pak Emirates Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Naveed Ahmed Combined Military Hospital, Quetta/National University of Medical Sciences (NUMS) Pakistan
  • Shafqat Rehman Pak Emirates Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Tamoor Afzal Pak Emirates Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Javed-Ur- Rehman Pak Emirates Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Iftikhar Ahmed Pak Emirates Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan

DOI:

https://doi.org/10.51253/pafmj.v73i1.5818

Keywords:

Barium enema, Hirscshprung disease, Rectal biopsy

Abstract

Objective: To determine the diagnostic accuracy of Barium contrast enema for diagnosis of Hirsch-sprung disease, taking histopathology as the gold standard.

Study Design: Cross-sectional validation study.

Place and Duration of Study: Department of Paediatric Surgery, Pak Emirates Military Hospital, Rawalpindi Pakistan, from Nov 2019 to May 2021.

Methodology: A total of 251 patients with symptoms of Hirsch-sprung disease were included. All patients were assessed with a Barium enema and full-thickness rectal biopsy. Barium enema was reported for the presence of contrast in the rectum after 24 hours, the presence or absence of transitional zone and a Recto Sigmoid Index less than 1. Full-thickness rectal biopsy was taken 2 cm above the dentate line, and histopathology was performed to see the ganglion cells in Meissner`s and Myenteric plexus.

Results: Histo-pathologically confirmed cases were 120(true positive), where 12(false positive) had no Hirsch-sprung disease on histopathology. In Barium enema negative patients, 113 were true negatives while 06 were false negatives. Overall sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy of Barium contrast enema for diagnosis of Hirsch-sprung disease were 95.24%, 90.40%, 90.91%, 94.96% and 92.83%, respectively.

Conclusion: We concluded that the diagnostic accuracy of Barium contrast enema for diagnosis of Hirsch-sprung disease is quite high, taking histopathology as the gold standard.

Downloads

Download data is not yet available.

Downloads

Published

28-02-2023

Issue

Section

Original Articles

How to Cite

1.
Anwar Z, Ahmed N, Rehman S, Afzal T, Rehman J-U-, Ahmed I. Diagnostic Accuracy of Barium Enema for the Diagnosis of Hirsch-sprung Disease in Children. Pak Armed Forces Med J [Internet]. 2023 Feb. 28 [cited 2024 Jun. 23];73(1):219-22. Available from: https://pafmj.org/PAFMJ/article/view/5818