ASSOCIATION OF STEROID RECEPTOR EXPRESSION WITH THE CLINICAL AND HISTOLOGICAL FINDINGS IN PATIENTS WITH ENDOMETRIAL CANCER: Steroid Receptor Expression in Endometrial Cancer

Aisha Shahid; Ghulam Haider; Paras Memon; Shumyla Beg; Mehwish Shahzadi; Kiran Abbas

doi:10.51253/pafmj.v71i5.5802

Authors

Aisha Shahid Jinnah Postgraduate Medical Center, Karachi Pakistan
Ghulam Haider Jinnah Postgraduate Medical Center, Karachi Pakistan
Paras Memon Jinnah Postgraduate Medical Center, Karachi Pakistan
Shumyla Beg Jinnah Postgraduate Medical Center, Karachi Pakistan
Mehwish Shahzadi Aga Khan University, Karachi Pakistan
Kiran Abbas Aga Khan University, Karachi Pakistan

DOI:

https://doi.org/10.51253/pafmj.v71i5.5802

Keywords:

ER expression, Endometrial Carcinoma, PR expression, Endometrioid cancer, Estrogen, Progesterone

Abstract

Objective: To determine the association of estrogen and progesterone receptor expression with the clinical and histological findings of endometrial cancer.

Study Design: Prospective observational study.

Place and Duration of Study: Jinnah Postgraduate Medical Centre, Karachi between Sep 2017 to Oct 2019.

Methodology: A total of 130 patients were diagnosed with endometrial carcinoma. Data from patient files were collected regarding tumour histology, grade, stage, tumour receptor expression, and the clinical characteristics: parity, menopausal status. The receptor expression profile was documented for each patient. Data were analyzed using SPSS version 25. The association between ER/PR expression categories and clinical/histological features were explored using the chi-square test.

Results: The estrogen and progesterone receptor expressions were significantly associated with low-grade (Grade I and II) tumours and with Stage I and Stage II endometrial carcinoma with p<0.001. About 34 (34.7%) cases of endometrioid histology were negative for both estrogen and progesterone receptors. The ER and PR negativity was strongly associated with Grade III endometrial cancer (p=0.003). The majority of the stage IV cancers were negative for both the ER and PR receptors with a p<0.001.

Conclusion: Estrogen and progesterone positivity was associated with endometrioid adenocarcinoma, well-differentiated, and less advanced stage of endometrial cancer at the time of diagnosis.