Impact of Enhanced Lipid Peroxidation on Carotid Artery Intima Media Thickness Ratio in Patients Receiving Maintenance Hemodialysis

Sadia Rehman; Tabassum Mahboob; Santosh Kumar; Syed Hidayat Ali; Muhammad Tassaduq Khan; Suniya Rehman

doi:10.51253/pafmj.v72i1.5725

Authors

Sadia Rehman Bahria University Medical and Dental College, Islamabad Pakistan
Tabassum Mahboob University of Karachi, Karachi Pakistan
Santosh Kumar Jinnah Sindh Medical University, Karachi Pakistan
Syed Hidayat Ali PSAQSJ Institute of Medical Sciences, Gambat, Khairpur Pakistan
Muhammad Tassaduq Khan Dow University of Medical and Dental College, Karachi Pakistan
Suniya Rehman Sir Ganga Ram Hospital, Lahore Pakistan

DOI:

https://doi.org/10.51253/pafmj.v72i1.5725

Keywords:

Hemodialysis, Intima-media thickness, Lipid peroxidation

Abstract

Objective: To determine the impact of increased lipid peroxidation on carotid intima media thickness ratio in patients receiving maintenance hemodialysis.

Study Design: Comparative prospective study.

Place and Duration of Study: Jinnah Post Graduate Medical Center Karachi in collaboration with University of Karachi, Pakistan, from Jan to Dec 2018.

Methodology: The hemodialysis patients were selected from the dialysis center where as the controls were recruited from normal healthy population. The cases taken were receiving maintenance hemodialysis thrice a week. Doppler ultrasonography technique was employed to detect the intima media thickness (IMT) ratio of common carotid artery of study subjects as well as controls. Lipid peroxidation was detected by serum oxidized LDL (ox-LDL) levels.

Results: The mean of right common carotid artery of group A samples was 0.45 ± 0.04 mm, left common carotid artery was 0.42 ± 0.01mm, and mean intima thickness was 0.43 ± 0.02 mm, the mean of right common carotid artery in group B was 0.93 ± 0.09 mm and mean of left common carotid in group B was 1.07 ± 0.14 mm and mean intima thickness of group B samples was 1.0 ± 0.09 mm. In group A mean Ox-LDL was 24.87 ± 5.23 U/ml while in group C samples mean Ox-LDL was 73.77 ± 6.77 U/ml.

Conclusion: Lipid peroxidation is much enhanced in patients on maintenance hemodialysis and leads to an increased carotid artery intima media thickness ratio which is a sign of development of atherosclerosis. This study will help the nephrologists in determining the causes..................