COMPARISON OF METFORMIN AND ORAL CONTRACEPTIVE PILLS IN THE TREATMENT OF POLYCYSTIC OVARIAN SYNDROME

Rabia Mushtaq; Sadaf Iqbal; Afroza Abbas; Bushra Iftikhar; Waqas Ahmed; Afeera Afsheen

doi:10.51253/pafmj.v71i4.5401

Authors

Rabia Mushtaq Sargodha Medical College, Sargodha Pakistan
Sadaf Iqbal Combined Military Hospital Hyderabad/National University of Medical Sciences (NUMS) Pakistan
Afroza Abbas Sargodha Medical College, Sargodha Pakistan
Bushra Iftikhar Pakistan Naval Ship Shifa Hospital, Karachi Pakistan
Waqas Ahmed 144 Medical Battalion/National University of Medical Sciences (NUMS) Pakistan
Afeera Afsheen Combined Military Hospital Multan/National University of Medical Sciences (NUMS) Pakistan

DOI:

https://doi.org/10.51253/pafmj.v71i4.5401

Keywords:

Body mass index, Metformin, Oral Contraceptives, Polycystic ovary syndrome, Testosterone

Abstract

Objective: To compare metformin and oral contraceptive pills in terms of mean change of serum testosterone levels and body mass index in polycystic ovarian syndrome.

Study Design: Quasi experimental study.

Place and Duration of Study: Department of Gynecology and Obstetrics, Sargodha Medical College, Sargodha Pakistan, from Apr to Dec 2019.

Methodology: A total of 64 patients presenting with polycystic ovarian syndrome between 15-35 years were included. All patients were divided into two groups i.e. group 1 received oral contraceptive pills, and group 2 received metformin. Patients were clinically evaluated at baseline and 6 months after initial presentation to address the primary aim of evaluating the change in mean serum testosterone levels and body mass index after treatment.

Results: The mean age of patients was 20.30 ± 4.92 years. The mean body mass index of patients at presentation was 30.32 ± 2.66 kg/m2. The mean reduction in the level of testosterone in group 1 was 5.14 ± 0.35ng/ml while in group 2 it was 2.58 ± 0.41 ng/ml (p˂ 0.001) which was statistically significant. Mean decrease in body mass index in group 1 was 1.51 ± 0.71 kg/m2 while in group 2 was 1.29 ± 0.46 kg/m2 (p=0.148) which was statistically insignificant.

Conclusion: Oral contraceptive pills were better than metformin in terms of mean decrease in serum testosterone levels in women presenting with polycystic ovarian syndrome while the mean reduction in body mass index in both the groups was similar.