COMPARISON OF EFFICACY OF CELECOXIB (SELECTIVE NON STEROIDAL ANTI INFLAMMATORY DRUG) VERSUS NAPROXEN (NON SELECTIVE NON STEROIDAL ANTI INFLAMMATORY DRUG) FOR POST ENDODONTIC PAIN

Abstract

Objective: To determine efficacy of celecoxib (selective cyclooxygenase - II non steroidal anti inflammatory drug) versus naproxen (non selective cyclooxygenase – I & II non steroidal anti inflammatory drug) for post endodontic pain.

Study Design: Comparative prospective study.

Place and Duration of Study: The study was executed at Department of Operative Dentistry, Armed Forces Institute of Dentistry (AFID), from Apr 2017 to Apr 2018.

Methodology: Total 961 patients (group A Celecoxib n=482 and group B Naproxen n=479) requiring root canal therapy were selected. The patient’s record regarding his pain perception using a visual analog scale (VAS) at 6 hours after root canal therapy was recorded. Descriptive statistics were used to calculate mean ± SD. for age and pain, before the procedure and after 6 hours of procedure in each groups.

Results: Total 961 patients were enrolled for the subject study out of which celecoxib group constituted 482 (50.1%) and naproxen group constituted 479 (49.8%) of total. 244 (50.6%) patients in group A (Celecoxib) exhibited adequate pain relief with no gastric discomfort and side effects whereas 195 (40.7%) patients had satisfactory pain relief in group B (Naproxen), however experienced gastric side effects such as nausea and dyspepsia.

Conclusion: Celecoxib was found to be more effective in post – endodontic pain with minimal gastric symptoms, when compared to Naproxen.