CONVALESCENT PLASMA FOR COVID-19 INFECTION: EVIDENCE AND CLINICAL APPLICATION

Authors

  • Ghassan Umair Shamshad Armed Forces Bone Marrow and Transplant Centre/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Raheel Iftikhar Armed Forces Bone Marrow and Transplant Centre/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Qamar Un Nisa Chaudhry Armed Forces Bone Marrow and Transplant Centre/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Jehanzeb Ur Rehman Armed Forces Bone Marrow and Transplant Centre/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Parvez Ahmed Armed Forces Bone Marrow and Transplant Centre/National University of Medical Sciences (NUMS) Rawalpindi Pakistan

Keywords:

Corona virus, Convalescent plasma, Mortality

Abstract

Corona virus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome corona virus 2 (SARS-CoV2) and has currently affected 11 million people worldwide with 0.53 million deaths. While there is ongoing trials and research for newer therapeutic options including antivirals (remdesivir), anti-interleukin 6 (tocilizumab), vaccines and antimalarials; there is renewed interest in the use of old therapeutic tools as well. Convalescent plasma has been used historically for measles, poliomyelitis, Spanish flu pandemic, severe acute respiratory syndrome (SARS1) and Ebola epidemics with conflicting results. With widespread use of convalescent plasma throughout the world as investigational drug for COVID-19, it is important to review past experience with its use in various outbreaks, potential role in COVID-19, and clinical application during current pandemic and challenges faced by resource constrained countries.

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Published

07-08-2020

Issue

Section

Short Communication

How to Cite

1.
Shamshad GU, Iftikhar R, Chaudhry QUN, Rehman JU, Ahmed P. CONVALESCENT PLASMA FOR COVID-19 INFECTION: EVIDENCE AND CLINICAL APPLICATION. Pak Armed Forces Med J [Internet]. 2020 Aug. 7 [cited 2024 Nov. 9];70(1):S418-20. Available from: https://pafmj.org/PAFMJ/article/view/4943