DETECTION OF STAT-1 IN PATIENTS CO-INFECTED WITH HEPATITIS B AND C RESISTANT TO INTERFERON
Stat-1 in Patients Co-Infected With Hepatitis-B
Keywords:
Co-infection, HBV, HCV, Interferon, STAT-1Abstract
Objective: Current study was designed to determine the STAT-1 in co-infected patients of hepatitis B and C resistant to interferon therapy. Study Design: Cross-sectional analytical study. Place and Duration of Study: Department of Biochemistry & Molecular Biology & Gastroenterology departments of various hospitals of Rawalpindi. Material and Methods: The study included 15 co-infected patients of hepatitis B and C resistant to interferon therapy and 15 healthy individuals as control. Methodology: Detection of STAT-1 was done by conventional PCR technique. Results: Sixty seven percent of the patients were expressing STAT-1 in their blood while 33% of the patients did not have STAT-1. Controls showed 57% detection of STAT-1 and 43% did not exhibit STAT-1. Mean age of the patients and controls was 35.90 ± 8.95.Comparison between patients and controls was done by chi square test. Fisher exact probability value obtained was 0.287 which was not significant. Conclusion: Patients suffering from hepatitis B and C co-infection resistant to interferon therapy revealed higher detection of STAT-1 which indicate greater liver damage, fibrosis and an extensive and severer disease course in co-infection.Downloads
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Published
30-04-2016
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Original Articles
How to Cite
1.
Manzoor N, Rashid A, Razak S, Majeed A. DETECTION OF STAT-1 IN PATIENTS CO-INFECTED WITH HEPATITIS B AND C RESISTANT TO INTERFERON: Stat-1 in Patients Co-Infected With Hepatitis-B. Pak Armed Forces Med J [Internet]. 2016 Apr. 30 [cited 2024 Sep. 1];66(2):216-20. Available from: https://pafmj.org/PAFMJ/article/view/488