COMPARISON BETWEEN THE EFFICACY OF PREGABALIN AND AMITRIPTYLINE IN ALLEVIATING PAIN ASSOCIATED WITH PAINFUL DIABETIC PERIPHERAL NEUROPATHY

Efficacy of Pregabalin And Amitriptyline in Alleviating Pain

Authors

  • Irfan Ali Soomro Combined Military Hospital Peshawar Pakistan
  • Fawad Ahmad Combined Military Hospital Peshawar Pakistan
  • Naveed Ahmed 75 Medical Battalion Pakistan

Keywords:

Alleviation of pain, Amitriptyline, Painful diabetic peripheral neuropathy, Pregabalin.

Abstract

Objective: To compare the efficacy of pregabalin and amitriptyline in alleviating pain associated with painful diabetic peripheral neuropathy (PDPN).
Study Design: Randomized controlled trial.
Place and Duration of Study: Department of Medicine, Pakistan Naval Ship (PNS) Shifa Karachi, from May 2014 to Nov 2014.
Material and Methods: Six hundred and sixty patients (330 in each group) with PDPN fulfilling the inclusion/exclusion criteria were randomized into groups A & B through consecutive non-probability sampling. Baseline pain scores on visual analogue scale (VAS) from 0-10 were recorded. Group-A was given pregabalin & group-B was given amitriptyline. Response was assessed after 6 weeks using VAS. A reduction of >50% on VAS was labeled efficacious.
Results: Out of 660 patients, 46.36% (n=153) in group-A and 57.88% (n=191) in group-B had effective relief of pain whereas 53.64% (n=177) in group-A and 42.12% (n=139) in group-B had persistent pain. A p-value was calculated as 0.003.
Conclusion: Amitriptyline was significantly more effective for alleviation of pain associated with PDPN when compared with pregabalin.

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Published

31-10-2018

Issue

Section

Original Articles

How to Cite

1.
Soomro IA, Ahmad F, Ahmed N. COMPARISON BETWEEN THE EFFICACY OF PREGABALIN AND AMITRIPTYLINE IN ALLEVIATING PAIN ASSOCIATED WITH PAINFUL DIABETIC PERIPHERAL NEUROPATHY: Efficacy of Pregabalin And Amitriptyline in Alleviating Pain. Pak Armed Forces Med J [Internet]. 2018 Oct. 31 [cited 2024 Nov. 4];68(2):198-201. Available from: https://pafmj.org/PAFMJ/article/view/437