OSTEOSARCOMA: PROGNOSIS AFTER STANDARD MANAGEMENT AND FACTOR RELATED TO GOOD PROGNOSIS

Abstract

Objective: To study the prognosis of osteosarcoma and factor related to good prognosis among patients managed at a tertiary care Military Hospital.

Study Design: Retrospective case series.

Place and Duration of Study: Department of Orthopedics and Pathology, CMH Hospital Rawalpindi, fro, 2010 to 2016.

Methodology: A total of 42 patients with histological diagnosis of osteosarcoma were picked up from the registers of Armed forces institute of pathology who were managed (neo-adjuvant chemotherapy, surgery and post-operative chemotherapy) at orthopedics and oncology department of Combined military hospital RWP. Patients were called on the telephone numbers mentioned in the register and two year status of disease along with socio-demographic data was recorded.

Results: Out of 42 patients with osteosarcoma included in the study, 24 (57.1%) had good prognosis while 18 (42.9%) had either died or were living with the disease. Low grade on Huvos grading and size of tumor <8cm had a statistically significant relationship with presence of good prognosis in the study population.

Conclusion: This study showed that after the standard management of osteosarcoma with neoadjuvant chemo-therapy, surgery and post-surgical chemotherapy the prognosis remains variable after two years. Tumors with smaller size and low grade at the time of diagnosis may have a good two ear prognosis.