Disseminated Intravascular Coagulation With Excessive Fibrinolysis (DIC-XFL) A Rare Association of Metastatic Prostate Adenocarcinoma: A Case Report

Authors

  • Muhammad Nadeem Department of Medical Oncology Combined Military Hospital Multan/National University of Medical Sciences (NUMS) Pakistan
  • Bilal Razzaq Department of Medical Oncology, Combined Military Hospital /National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Nayab Khan Department of Medical Oncology, Combined Military Hospital /National University of Medical Sciences (NUMS) Rawalpindi Pakistan

DOI:

https://doi.org/10.51253/pafmj.v74i1.3718

Keywords:

Adenocarcinoma, Disseminated intravascular coagulation, Excessive fibrinolysis, Prostate cancer

Abstract

We present disseminated intravascular coagulation (DIC) with excessive fibrinolysis (XFL) as an unusual presenting
manifestation of metastatic prostate cancer (PC), which was successfully treated with chemotherapy with Docetaxel which not
only controlled the disease but also reversed the patient’s coagulopathy within seven days effectively. Thus highlighting rare
and life-threatening haemorrhagic complications of prostate cancer along with its satisfactory management option.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

References

de la Fouchardière C, Flechon A, Droz JP. Coagulopathy in

prostate cancer. Neth J Med 2003; 61(11): 347-354.

Jemal A, Siegel R, Ward E, Murray T, Xu J, Smigal C,et al.

Cancer statistics, 2006. CA Cancer J Clin 2006 ; 56(2): 106-130.

https://doi: 10.3322/canjclin.56.2.106.

Duran I, Tannock IF. Disseminated intravascular coagulation

as the presenting sign of metastatic prostate cancer. J Gen

Intern Med 2006; 21(11): C6-8. https://doi.org/10.1111/j.1525-

2006.00506.x.

Hamzah AB, Choo YM, Hassali MA, Saleem F, Verma AK.

Disseminated Intravascular Coagulation and Excessive

Fibrinolysis (DIC XFL) Syndrome in Prostate Cancer: A Rare

Complicated Disorder. J Clin Diagn Res 2017; 11(1): XD01-

XD02. https://doi.org/10.7860/JCDR/2017/22582.9313.

Litt MR, Bell WR, Lepor HA. Disseminated intravascular

coagulation in prostatic carcinoma reversed by ketoconazole.

JAMA 1987; 258(10): 1361-1362.

Wada Y, Uchiba M, Kawano Y, Kai N, Takahashi W, Honda J,

et al. Severe bleeding tendency caused by a rare complication

of excessive fibrinolysis with disseminated intravascular

coagulation in a 51-year-old Japanese man with prostate

cancer: a case report. J Med Case Rep 2012; 6: 378.

https://doi.org/10.1186/1752-1947-6-378.

Sallah S, Gagnon GA. Reversion of primary

hyperfibrinogenolysis in patients with hormone-refractory

prostate cancer using docetaxel. Cancer Invest 2000; 18(3): 191-

https://doi.org/10.3109/07357900009031823.

Avancès C, Jacot W, Sénesse P, Culine S. Prompt resolution of

acute disseminated intravascular coagulation with docetaxel

and cisplatin in hormone refractory prostate cancer. J Urol

; 168(4 Pt 1): 1496. https://doi.org/10.1016/S0022-

(05)64487-4.

Sweeney CJ, Chen YH, Carducci M, Liu G, Jarrard DF,

Eisenberger M, et al. Chemohormonal Therapy in Metastatic

Hormone-Sensitive Prostate Cancer. N Engl J Med 2015 ;

(8): 737-746. https://doi.org/10.1056/NEJMoa1503747.

Ong SY, Taverna J, Jokerst C, Enzler T, Hammode E, Rogowitz

E, et al. Prostate Cancer-Associated Disseminated Intravascular

Coagulation with Excessive Fibrinolysis Treated with

Degarelix. Case Rep Oncol Med 2015; 2015: 212543.

https://doi.org/10.1155/2015/212543

Downloads

Published

28-02-2024

How to Cite

Nadeem, M., Razzaq, B., & Khan, N. (2024). Disseminated Intravascular Coagulation With Excessive Fibrinolysis (DIC-XFL) A Rare Association of Metastatic Prostate Adenocarcinoma: A Case Report. Pakistan Armed Forces Medical Journal, 74(1), 248–249. https://doi.org/10.51253/pafmj.v74i1.3718

Issue

Section

Case Reports

Most read articles by the same author(s)

1 2 > >>