Disseminated Intravascular Coagulation With Excessive Fibrinolysis (DIC-XFL) A Rare Association of Metastatic Prostate Adenocarcinoma: A Case Report
DOI:
https://doi.org/10.51253/pafmj.v74i1.3718Keywords:
Adenocarcinoma, Disseminated intravascular coagulation, Excessive fibrinolysis, Prostate cancerAbstract
We present disseminated intravascular coagulation (DIC) with excessive fibrinolysis (XFL) as an unusual presenting
manifestation of metastatic prostate cancer (PC), which was successfully treated with chemotherapy with Docetaxel which not
only controlled the disease but also reversed the patient’s coagulopathy within seven days effectively. Thus highlighting rare
and life-threatening haemorrhagic complications of prostate cancer along with its satisfactory management option.
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References
de la Fouchardière C, Flechon A, Droz JP. Coagulopathy in
prostate cancer. Neth J Med 2003; 61(11): 347-354.
Jemal A, Siegel R, Ward E, Murray T, Xu J, Smigal C,et al.
Cancer statistics, 2006. CA Cancer J Clin 2006 ; 56(2): 106-130.
https://doi: 10.3322/canjclin.56.2.106.
Duran I, Tannock IF. Disseminated intravascular coagulation
as the presenting sign of metastatic prostate cancer. J Gen
Intern Med 2006; 21(11): C6-8. https://doi.org/10.1111/j.1525-
2006.00506.x.
Hamzah AB, Choo YM, Hassali MA, Saleem F, Verma AK.
Disseminated Intravascular Coagulation and Excessive
Fibrinolysis (DIC XFL) Syndrome in Prostate Cancer: A Rare
Complicated Disorder. J Clin Diagn Res 2017; 11(1): XD01-
XD02. https://doi.org/10.7860/JCDR/2017/22582.9313.
Litt MR, Bell WR, Lepor HA. Disseminated intravascular
coagulation in prostatic carcinoma reversed by ketoconazole.
JAMA 1987; 258(10): 1361-1362.
Wada Y, Uchiba M, Kawano Y, Kai N, Takahashi W, Honda J,
et al. Severe bleeding tendency caused by a rare complication
of excessive fibrinolysis with disseminated intravascular
coagulation in a 51-year-old Japanese man with prostate
cancer: a case report. J Med Case Rep 2012; 6: 378.
https://doi.org/10.1186/1752-1947-6-378.
Sallah S, Gagnon GA. Reversion of primary
hyperfibrinogenolysis in patients with hormone-refractory
prostate cancer using docetaxel. Cancer Invest 2000; 18(3): 191-
https://doi.org/10.3109/07357900009031823.
Avancès C, Jacot W, Sénesse P, Culine S. Prompt resolution of
acute disseminated intravascular coagulation with docetaxel
and cisplatin in hormone refractory prostate cancer. J Urol
; 168(4 Pt 1): 1496. https://doi.org/10.1016/S0022-
(05)64487-4.
Sweeney CJ, Chen YH, Carducci M, Liu G, Jarrard DF,
Eisenberger M, et al. Chemohormonal Therapy in Metastatic
Hormone-Sensitive Prostate Cancer. N Engl J Med 2015 ;
(8): 737-746. https://doi.org/10.1056/NEJMoa1503747.
Ong SY, Taverna J, Jokerst C, Enzler T, Hammode E, Rogowitz
E, et al. Prostate Cancer-Associated Disseminated Intravascular
Coagulation with Excessive Fibrinolysis Treated with
Degarelix. Case Rep Oncol Med 2015; 2015: 212543.
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