SUDDEN CARDIAC DEATH: VULNERABILITY OF ATHEROSCLEROTIC PLAQUE IN CORONARY ARTERIES: Atherosclerotic Plaque in Coronary Arteries

Sumaira Bukhsh; Samia Nasreen; Hassan Tariq; Syed Salman Ali; Muhammad Umer; Nadeem Zafar; Hafeez Ud Din

doi:10.51253/pafmj.v71i5.3621

Authors

Sumaira Bukhsh Combined Military Hospital Malir/National University of Medical Sciences (NUMS) Pakistan
Samia Nasreen Combined Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
Hassan Tariq Armed Forces Institute of Pathology/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
Syed Salman Ali Combined Military Hospital Abbottabad/National University of Medical Sciences (NUMS) Pakistan
Muhammad Umer Pakistan Naval Ship Hospital, Karachi Pakistan
Nadeem Zafar Armed Forces Institute of Pathology/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
Hafeez Ud Din Armed Forces Institute of Pathology/National University of Medical Sciences (NUMS) Rawalpindi Pakistan

DOI:

https://doi.org/10.51253/pafmj.v71i5.3621

Keywords:

Atherosclerotic plaque, Cluster of differentiation 68, Cluster of differentiation 105, Nuclear Factor-kappa-light-chainenhancer of activated B cells, Vulnerability

Abstract

Objective: To assess the vulnerability of atherosclerotic plaque in coronary arteries of individuals dying of ischemic heart disease.

Study Design: Cross sectional study.

Place and Duration of Study: Histopathology department, Combined Military Hospital Lahore, from Nov 2016 to Nov 2017.

Methodology: A total of 43 cases were taken in the study. The Autopsy specimens from the bodies of people dying suddenly of ischemic heart disease were taken into the study. Tissues showing autolytic changes and patients dying with coronary artery disease after corrective procedure like stenting and bypass were excluded.

Results: Out of 43 cases, 35 (81.4%) cases were positive for cluster of differentiation 68 (CD 68), 34 (79%) cases were positive for cluster of differentiation 105 (CD 105) & 36 (83.6) cases were positive for nuclear factor kappa-light-chain-enhancer of activated B cells (NF-Kb).

Conclusion: People who had died of ischemic heart disease have more vulnerable plaque in their coronary arteries as compared to the people who had died of non-ischemic cause. Early recognition of the un-ruptured plaque is important for the treatment strategies.