TO COMPARE THE EFFECTS OF PITAVASTATIN ON INSULIN RESISTANCE IN PATIENTS WITH TYPE 2 DIABETES MELLITUS WITH HPERCHOLESTEROLEMIA WHO WERE PREVIOUSLY BEING TREATED WITH ATOORVSTATIN

Authors

  • Shahid Abbas Combined Military Hospital, Sialkot Pakistan
  • Muhammad Nadir Khan Army Cardiac Center, Lahore Pakistan
  • Naseer Ahmed Samor Pakistan Naval Ship (PNS), Shifa Karachi Pakistan
  • Humzah Abbas HBS Medical College, Islamabad Pakistan
  • Raheem Pervaiz Khan Shifa Medical College, Islamabad Pakistan
  • Javeria Kamran Armed Forces Institute of Cardiology/ National Institute of Heart Disease (AFIC/NIHD)/National University of Medical Sciences (NUMS), Rawalpindi Pakistan

Keywords:

Glycemic control, , Lipid Profile, Statin, Type 2 diabetes mellitus

Abstract

Objective: To compare the effects of Pitavastatin on Insulin Resistance in patients with type 2 diabetes mellitus with hypercholesterolemia who were previously being treated with Atorvastatin.

Study Design: Prospective, comparative cross-sectional study.

Place and Duration of Study: Combined Military Hospital Sialkot, from Sep 2018 to Dec 2018.

Methodology: Our study was a prospective, comparative cross-sectional study, formulated to evaluate the effects of statins on Insulin resistance. A total of 52 patients of Diabetes Mellitus and Hypercholesterolemia who were previously treated with Atorvastatin for at least 12 weeks were enrolled for the study carried out for 3 months. Serum lipid profiles and blood samples were obtained after overnight fast. Insulin resistance was calculated at the start of study for atorvastatin and after 3 months of shifting to Pitavastatin.

Results: At initiation of the study no statistically significant differences were found in the baseline BMI, HDL-C, triglycerides or HbA1c. Homeostatic Model Assessment of Insulin Resistance (HOMA_IR) was employed to calculate Insulin resistance at the start of study and after 3 months of shifting to Pitavastatin. There was a significant reduction in Insulin resistance (p=0.031) after three months of shifting the patient from Atorvastatin to Pitavastatin.

Conclusion: Pitavastatin treatment in comparison to Atorvastatin had statistically significant reduction in Insulin resistance in patients with type 2 Diabetes Mellitus.

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Published

29-11-2019

How to Cite

Abbas, S., Khan, M. N., Samor, N. A., Abbas, H., Khan, R. P., & Kamran, J. (2019). TO COMPARE THE EFFECTS OF PITAVASTATIN ON INSULIN RESISTANCE IN PATIENTS WITH TYPE 2 DIABETES MELLITUS WITH HPERCHOLESTEROLEMIA WHO WERE PREVIOUSLY BEING TREATED WITH ATOORVSTATIN. Pakistan Armed Forces Medical Journal, 69(Suppl-3), S393–98. Retrieved from https://pafmj.org/PAFMJ/article/view/3549

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Original Articles

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