TO COMPARE THE EFFECTS OF PITAVASTATIN ON INSULIN RESISTANCE IN PATIENTS WITH TYPE 2 DIABETES MELLITUS WITH HPERCHOLESTEROLEMIA WHO WERE PREVIOUSLY BEING TREATED WITH ATOORVSTATIN

Authors

  • Shahid Abbas Combined Military Hospital, Sialkot Pakistan
  • Muhammad Nadir Khan Army Cardiac Center, Lahore Pakistan
  • Naseer Ahmed Samor Pakistan Naval Ship (PNS), Shifa Karachi Pakistan
  • Humzah Abbas HBS Medical College, Islamabad Pakistan
  • Raheem Pervaiz Khan Shifa Medical College, Islamabad Pakistan
  • Javeria Kamran Armed Forces Institute of Cardiology/ National Institute of Heart Disease (AFIC/NIHD)/National University of Medical Sciences (NUMS), Rawalpindi Pakistan

Keywords:

Glycemic control, , Lipid Profile, Statin, Type 2 diabetes mellitus

Abstract

Objective: To compare the effects of Pitavastatin on Insulin Resistance in patients with type 2 diabetes mellitus with hypercholesterolemia who were previously being treated with Atorvastatin.

Study Design: Prospective, comparative cross-sectional study.

Place and Duration of Study: Combined Military Hospital Sialkot, from Sep 2018 to Dec 2018.

Methodology: Our study was a prospective, comparative cross-sectional study, formulated to evaluate the effects of statins on Insulin resistance. A total of 52 patients of Diabetes Mellitus and Hypercholesterolemia who were previously treated with Atorvastatin for at least 12 weeks were enrolled for the study carried out for 3 months. Serum lipid profiles and blood samples were obtained after overnight fast. Insulin resistance was calculated at the start of study for atorvastatin and after 3 months of shifting to Pitavastatin.

Results: At initiation of the study no statistically significant differences were found in the baseline BMI, HDL-C, triglycerides or HbA1c. Homeostatic Model Assessment of Insulin Resistance (HOMA_IR) was employed to calculate Insulin resistance at the start of study and after 3 months of shifting to Pitavastatin. There was a significant reduction in Insulin resistance (p=0.031) after three months of shifting the patient from Atorvastatin to Pitavastatin.

Conclusion: Pitavastatin treatment in comparison to Atorvastatin had statistically significant reduction in Insulin resistance in patients with type 2 Diabetes Mellitus.

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Published

29-11-2019

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Original Articles

How to Cite

1.
Abbas S, Khan MN, Samor NA, Abbas H, Khan RP, Kamran J. TO COMPARE THE EFFECTS OF PITAVASTATIN ON INSULIN RESISTANCE IN PATIENTS WITH TYPE 2 DIABETES MELLITUS WITH HPERCHOLESTEROLEMIA WHO WERE PREVIOUSLY BEING TREATED WITH ATOORVSTATIN. Pak Armed Forces Med J [Internet]. 2019 Nov. 29 [cited 2024 Oct. 15];69(Suppl-3):S393-98. Available from: https://pafmj.org/PAFMJ/article/view/3549