IMMUNOEXPRESSION OF CD-10 IN BASAL CELL CARCINOMA AND SQUAMOUS CELL CARCINOMA OF HEAD AND NECK

Maria Ilyas; Muhammad Yasir Rafiq; Farha Farhan; Misbah Ali; Saeed Afzal; Zainab Niazi

doi:10.51253/pafmj.v71i6.3495

Authors

Maria Ilyas Baqai Dental College, Karachi Pakistan
Muhammad Yasir Rafiq Combined Military Hospital Malir/National University of Medical Sciences (NUMS) Pakistan
Farha Farhan Foundation College of Dentistry, Islamabad Pakistan
Misbah Ali Margalla Institute of Health Sciences, Islamabad Pakistan
Saeed Afzal Alicenna Medical College, Lahore Pakistan
Zainab Niazi Islamabad Medical & Dental College, Islamabad Pakistan

DOI:

https://doi.org/10.51253/pafmj.v71i6.3495

Keywords:

Basal Cell Carcinoma (BCC), CD-10, Squamous cell carcinoma (SCC)

Abstract

Objective: To compare the expression of CD-10 in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC).

Study Design: Comparative cross-sectional study.

Place and Duration of Study: Armed Forces Institute of Pathology, Rawalpindi, from Jun 2016 to Jun 2017.

Methodology: After taking ethics approval from the ethical review committee AFIP, previously diagnosed, thirty-eight cases of each basal cell carcinoma and squamous cell carcinoma were taken from the histopathology department of Armed Forces Institute of Pathology, Rawalpindi. CD-10 was applied according to standard protocol. The intensity of the CD-10 expression is assessed and categorized into three groups. CD-10 expression less than 10% in the tumour cell was taken as negative (-), 10 to 50% staining was taken as positive (+) and greater than 50% staining in tumour cells was taken as strong positive (++).

Results: Out of the total 76 cases included in the study, 9 (24%) were strongly positive (++) whereas 20 (52.6%) were positive (+) and 9 (23.7%) were negative (-) for CD-10 expression. Out of the total 38 cases of SCC 4 (11%) cases showed positive CD-10 expression and 34 (89%) showed negative (-) results. A significant association (p-value <0.001) was seen when CD-10 expression in BCC was compared with SCC.

Conclusion: CD-10 expression was higher in basal cell carcinoma when compared to squamous cell carcinoma in which CD-10 expression was very low/absent, hence CD-10 can serve as a useful adjunct marker in differentiating between basal cell carcinoma and squamous cell carcinoma in problematic cases.