THE EFFECT OF PAMIDRONATE ON BONE MINERAL DENSITY IN PRIMARY OSTEOPOROSIS IN PAKISTANI POPULATION

Pamidronate on Bone Mineral Density

Abstract

Objective: To study the protective effect of Bisphosphonates (Pamidronate) in patients of primary osteoporosis in Pakistani setup.
Study Design: Quasi experimental study.
Place and Duration of Study: The study was carried out at department of orthopedic and spine surgery, CMH Rawalpindi, from Sep 2011 to Sep 2013.
Material and Methods: A non probability convenience sample was collected from 50 patients who visited orthopaedics department with complaints of generalized aches and pains and diagnosed to have primary osteoprosis. Osteoporosis was confirmed by DEXA scan, with a T-score of more than -2.5. Pamidronate-a bisphosphonate, was given I/V on monthly basis along with oral calcium. After 6 month and one year DEXA scan was repeated to observe its effect on bone mineral density
Results: Osteoporosis T score of DEXA scan was seen to improve by 19.3% (0.193 T score improvement) with a p-value less than 0.05.
Conclusion: Pamidronate treatment increased bone mineral density in osteoprotic patients.