COMPARISON OF HAEMODYNAMIC EFFECT OF EQUIVALENT DOSE OF OXYTOCIN GIVEN AS BOLUS AND IN FUSION

Abstract

Objective:

To compare the haemodynamic effects of equivalent dose of oxytocin given as an intravenous bolus and as infusion. Study Design: Randomized controlled trial. Place and Duration of Study: CMH Rawalpindi from Jan 2016 to Jul 2016. Material and Methods: This randomized control trial was conducted after approval of ethical committee of the hospital and a total 90 patients, American society of anesthesiologists physical status I or II, were included in this study. Patients were divided into two groups (n=45), group-A received oxytocin (5 IU) approximately over 10 seconds as an intravenous bolus and group-B received (5 IU) over 5 minutes as an infusion in infusion pump. Mean heart rate and mean blood pressure recorded at Baseline 0, 1, 5, 10 and 15 minutes. The hemodynamic data was compared between the groups.
Results:

The Oxytocin when administered as an intravenous infusion showed statistically significant effects on heart rate when compared with bolus group from 1 minute to 15 minute (p<0.001). Similarly, oxytocin once administered as an intravenous infusion showed statistically significant difference in mean arterial pressure (MAP) when compared with bolus group from 1 minute to 15 minute (p<0.001).

Conclusion:

It is concluded that oxytocin (5IU) once administered as an infusion during elective caesarean section causes less haemodynamic changes.