CLOMIPHENE CITRATE: A TREATMENT OF IDIOPATHIC OLIGOSPERMIA IN MALE INFERTILITY

Clomiphene Citrate

Abstract

Objective: To determine the efficacy of clomiphene citrate therapy in improving seminal parameters of idiopathic oligospermic male partners.
Study design: Quasi-experimental study.
Place and duration: Department of Urology, Combined Military Hospital, Lahore from June 2008 to June 2010.
Materials and methods: This study was conducted in a sample of 50 idiopathic oligospermic men from local population. Clomiphene citrate was administered at a dose of 50 mg per day for 25 days followed by a 5 day rest. The cycle was continued for 03 months. Strict inclusion and exclusion criteria were followed.
Results: Repeat semen analysis was done at the end of 03 months and all the routine seminal parameters were re-evaluated. Clomiphene citrate administration resulted in statistically highly significant increase in semen volume (p<0.001), sperm density (p<0.001) and total sperm motility (p<0.001).
Conclusion: As clomiphene citrate leads to endogenous gonadotrophin increase, when there is no end organ pathology, this increase results in improving semen volume, sperm count, sperm motility and to a certain extent sperm morphology.