Procalcitonin in Predicting Sepsis in Patients Presenting In Emergency Department with Acute Ureteric Colic Due to Stone

Hassan  Sajid; Qamar  Zia; Quratul Ann  Mustafa; Muhammad Tanveer Sajid; Haroon Sabir  Khan; Hussain  Ahmad

doi:10.51253/pafmj.v76iSUPPL-6.13859

Authors

Hassan Sajid Department of Urology, Armed Forces Institute of Urology, Rawalpindi/National University of Medical Sciences (NUMS) Pakistan
Qamar Zia Department of Urology, Armed Forces Institute of Urology, Rawalpindi/National University of Medical Sciences (NUMS) Pakistan
Quratul Ann Mustafa Department of Chemical Pathology, Army Medical College, Rawalpindi/National University of Medical Sciences (NUMS) Pakistan
Muhammad Tanveer Sajid Department of Urology, Armed Forces Institute of Urology, Rawalpindi/National University of Medical Sciences (NUMS) Pakistan
Haroon Sabir Khan Department of Urology, Armed Forces Institute of Urology, Rawalpindi/National University of Medical Sciences (NUMS) Pakistan
Hussain Ahmad Department of Urology, Armed Forces Institute of Urology, Rawalpindi/National University of Medical Sciences (NUMS) Pakistan

DOI:

https://doi.org/10.51253/pafmj.v76iSUPPL-6.13859

Keywords:

Procalcitonin, Sepsis, urinary tract infection, Urinary calculi

Abstract

Objective: To determine the prognostic value of serum procalcitonin levels in predicting sepsis severity and outcomes in patients presenting to the emergency department with urinary tract infections (UTIs) complicated by urinary tract calculi.

Study Design: Cross sectional study.

Place and Duration of Study: Armed Forces Institute of Urology (AFIU), Rawalpindi, Pakistan from Nov 2024 to Apr 2025.

Methodology: A cohort of 150 adult patients with confirmed UTIs and urinary stones based on clinical, laboratory, and radiological diagnosis were included via nonprobability consecutive sampling. Patients on corticosteroids, immunosuppressants, or chemotherapy, antibiotics, pregnant women, and those with chronic kidney disease, were excluded from the study. Procalcitonin (PCT) was measured using electrochemiluminescence immunoassay. Data collected on clinical and radiologic characteristics, demographics, comorbidities, sepsis classification according to Sepsis-3 criteria.

Results: Among the 150 patients, 68(45.3%) were female, while 82(54.7%) were male 91 patients (60–70%) had ureteric stones, and 66 patients (44.0%), had hydronephrosis. 42.0% had sepsis, 14.0% had severe sepsis, and 3-7% had septic shock. The severity of sepsis was positively correlated with median PCT levels (p<0.001). ICU admission and 7-day mortality were significantly higher in patients with procalcitonin levels > 2 ng/mL and having diabetes, and hydronephrosis.

Conclusion: PCT levels can significantly provide risk stratification for sepsis severity in patients with UTIs complicated by urinary tract stones, directing timely and effective treatment and enhancing patient outcomes.

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