Diagnostic Accuracy of Diffusion Weighted Imaging in Diagnosing Malignant Ovarian Lesions Keeping Histopathology as the Gold Standard

Tooba  Rehman; Hussain Rashid  Ihsan; Nosheen  Sadiq; Tabassum  Rasul; Hassan  Tariq

doi:10.51253/pafmj.v76iSUPPL-6.13560

Authors

Tooba Rehman Department of Radiology, Combined Military Hospital, Multan/National University of Medical Sciences (NUMS) Pakistan
Hussain Rashid Ihsan Department of Radiology, Combined Military Hospital, Multan/National University of Medical Sciences (NUMS) Pakistan
Nosheen Sadiq Department of Radiology, Combined Military Hospital, Multan/National University of Medical Sciences (NUMS) Pakistan
Tabassum Rasul Department of Radiology, Combined Military Hospital, Multan/National University of Medical Sciences (NUMS) Pakistan
Hassan Tariq Department of Histopathology, Combined Military Hospital, Multan/National University of Medical Sciences (NUMS) Pakistan

DOI:

https://doi.org/10.51253/pafmj.v76iSUPPL-6.13560

Keywords:

Apparent diffusion coefficient (ADC), Diagnostic accuracy, Diffusion weighted imaging, Ovarian mass, Sensitivity, Specificity

Abstract

Objective: To determine the accuracy of diffusion weighted imaging (DWI) and apparent diffusion coefficient (ADC) value in diagnosing malignant ovarian lesions.

Study Design: Cross-sectional study.

Place and Duration of Study: Department of Radiology, Combined Military Hospital, Multan Pakistan, from Jun 2024 to May 2025.

Methodology: A total of 58 patients were enrolled in this study. They were first subjected to DWI, and ADC values were calculated to categorize ovarian masses as benign/malignant. Later, all patients underwent excision of the mass, followed by histopathological categorization of the mass as benign or malignant. The diagnostic accuracy, sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of DWI in diagnosing malignant ovarian lesions were determined.

Results: Mean age was 50.03±6.68 years, while mean BMI was 26.44±2.40 kg/m2. ADC values of malignant tumors showed a mean of 1.08 × 10-3 mm2/s±0.014, with a p-value <0.001 (highly statistically significant). Sensitivity 83.33%, specificity 80.00%, PPV 95.24%, NPV 50%, and overall diagnostic accuracy 82.76% of DWI MRI in differentiating benign and malignant ovarian masses.

Conclusion: DWI with ADC value has good sensitivity and specificity in differentiating benign from malignant ovarian lesions.

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