Correlation of Ultrasound and histopathology for diagnosis of endometrial cancer in post-menopausal women
DOI:
https://doi.org/10.51253/pafmj.v76iSUPPL-6.13249Keywords:
Biopsy, Endometrium, Hemorrhage, Menopause, Neoplasm, Sensitivity, Specificity, Ultrasonography and UterusAbstract
Objective: To determine the usefulness of trans-vaginal ultrasonography for diagnosis of endometrial carcinoma as screening tool by comparing sonographic thickness of endometrium and histopathology in post-menopausal women.
Study Design: Quasi-experimental study.
Place and Duration of Study: Pak Emirates Military Hospital, Rawalpindi Pakistan, from Jan 2024 to Jan 2025.
Methodology: After seeking approval of ethical commission, we recruited two Groups of post-menopausal ladies presented with abnormal uterine bleeding, one with normal endometrial thickness and another with abnormal endometrial thickness. We did transvaginal ultrasonography on all patients and performed histopathology of their endometrial tissue taken on biopsy. We compared the frequency of positive cases on histopathology and correlated it to their sonographic findings by calculating sensitivity and specificity to establish diagnostic yield of trans-vaginal ultrasonography in endometrial carcinoma.
Results: The sensitivity of trans-vaginal ultrasonography in diagnosis of carcinoma of endometrium was 64.1%, specificity was 92.0%, positive predictive value was 58.6% and negative predictive value was 79.8%. The frequency of carcinoma was 23(35.9%) in Group-A and it was 2(3.3%) in Group-B with p-value of <0.001.
Conclusion: We came to conclusion that trans-vaginal ultrasonography can be utilized as consistent screening tool for detection of carcinoma endometrium
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1. Ejaz S, Ejaz M, Kalsoom U, Kamran M, Ahsan D, Qamar S. Study of Histopathological Pattern of Endometrial Curettings and Healthcare Burden due to Inadequate Samples. Pak J Med Health Sci 2022; 16(04): 36-.
https://doi.org/10.53350/pjmhs2216436
2. Gultekin M, Kucukyildiz I, Karaca MZ, Dundar S, Boztas G, Turan SH, Hacikamiloglu E, Keskinkilic B. Trends of gynecological cancers in Turkey: toward Europe or Asia?. Int J Gynecol Cancer 2017; 27(7): 1026.
https://doi.org/10.1097/IGC.0000000000001026
3. Uharček P. Prognostic factors in endometrial carcinoma. J Obstet Gynaecol Res 2008; 34(5): 776-83.
https://doi.org/10.1111/j.1447-0756.2008.00796.x
4. Garg S, Kalhan S, Saini N, Sharma P, Misra S. Study of spectrum of endometrial pathology in patients with abnormal uterine bleeding and its clinicopathological correlation. Int J Clin Diag Pathol 2020; 3(1): 88-91. http://www.ijrcog.org/index.php
5. Pertyńska-Marczewska M, Pertyński T. Postmenopausal women in gynecological care. Menopause Rev 2021; 20(2): 88-98.
https://doi.org/10.5114/pm.2021.107103
6. Gentry-Maharaj A, Karpinskyj C. Current and future approaches to screening for endometrial cancer. Best Pract Res Clin Obstet Gynaecol 2020; 65: 79-97.
https://doi.org/10.1016/j.bpobgyn.2019.12.006
7. Günakan E, Atak Z, Albayrak M, Kurban Y, Şimşek GG. Endometrial histopathology results and evaluation of endometrial cancer risk in geriatric women. Prz Menopauzalny 2018; 17(1): 18-21.
https://doi.org/10.4021/jocmr1684w
8. Seebacher V, Schmid M, Polterauer S, Hefler-Frischmuth K, Leipold H, Concin N, et al. The presence of postmenopausal bleeding as prognostic parameter in patients with endometrial cancer: a retrospective multi-center study. BMC Cancer 2009; 9: 1-5. https://doi.org/10.1186/1471-2407-9-460
9. Pessoa JN, Freitas AC, Guimaraes RA, Lima J, Dos Reis HL, Chambo Filho A. Endometrial assessment: when is it necessary?. J Clin Med Res 2014; 6(1): 21.
https://doi.org/10.4021/jocmr1684w
10. Davis E, Sparzak PB. Abnormal Uterine Bleeding. [Updated 2023 Sep 4]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024.
https://www.ncbi.nlm.nih.gov/books/NBK532913/
11. Gupta JK, Chien PF, Voit D, Clark TJ, Khan KS. Ultrasonographic endometrial thickness for diagnosing endometrial pathology in women with postmenopausal bleeding: a meta-analysis. Acta obstetricia et Gynecologica Scandinavica 2002; 81(9): 799-816.
https://doi.org/10.1080/j.1600-0412.2001.810902.x
12. Akhter MK, Khadija S, Majid N, Yousaf H, Rehman UA, Iftikhar A, et al. Correlation of Endometrial Thickness and Endometrial Histology in Post-Menopausal patients. Pak J Med Health Sci 2022; 16(04): 4-6.
https://doi.org/10.53350/pjmhs221644
13. Jo HC, Baek JC, Lee SM, Park JE, Cho IA, Sung JH. Clinicopathological and ultrasound features of endometrial cancer in postmenopausal women: a retrospective study in a single institute in South Korea. Pan Afr Med J Conf Proc 2021; 38(1): 287.
14. Mahapatra S, Chavan NN, Mirza H, Rajput H. Correlation of ultrasound, hysteroscopic and endometrial histopathology findings in patients with post-menopausal bleeding. Int J Reproduct Contracept Obstet Gynecol 2022; 11(5): 1540.
https://dx.doi.org/10.18203/2320-1770.ijrcog20221290
15. Mohamed A, Elgarhy IT, Elboghdady AA. Relationship between transvaginal ultrasound endometrial thickness, body mass index and endometrial pathology in women with post-menopausal bleeding. Al-Azhar Int Med J 2021; 2(6): 33-40.
https://dx.doi.org/10.21608/aimj.2021.62095.1460
16. Bibi S, Khan TM, Zafar WM, Umer MJ, Iqbal UF, Maqsood MA, Khan S, Khalil S, Mumtaz M. Prevalence of obesity and impact of menopause on It among women of rural area of Punjab, Pakistan. Eur J Medical Health Sci 2021; 3(1): 108-111.
https://dx.doi.org/10.24018/ejmed.2021.3.1.682
17. Stoenescu V, Novac MB, Dijmarescu L, Manolea M, Novac L, Tomescu P, et al. The Importance of the Correlation between the Ultrasonographic Evaluation of Endometrium and Histopathological Findings in Patients with Endometrial Hyperplasia and Carcinoma. Curr Health Sci J 2017; 43(2): 149-152. https://dx.doi.org/10.12865/CHSJ.43.02.07
18. Beeresh CS, Doopadapalli D, Gangadharan K, Pradeep S. Assessment of endometrial thickness by ultrasonography and its histological correlation in postmenopausal women. Int J Clin Obstet Gynaecol 2020; 4(1): 243-247.
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