Role of Desmopressin in Prevention of Post Dural Puncture Headache after C-Section

Tabassum Muzaffar; Sadia Fatima

doi:10.51253/pafmj.v76iSUPPL-6.12843

Authors

Tabassum Muzaffar Department of Gynecology and Obstetrics, Combined Military Hospital/National University of Medical Sciences (NUMS), Rawalpindi Pakistan
Sadia Fatima Department of Gynecology and Obstetrics, Combined Military Hospital/National University of Medical Sciences (NUMS), Rawalpindi Pakistan

DOI:

https://doi.org/10.51253/pafmj.v76iSUPPL-6.12843

Keywords:

Cesarean-Section, Desmopressin, Post Dural Puncture Headache (PDPH)

Abstract

Objective: To determine the role of Desmopressin in prevention of post dural puncture headache after C-section.

Study Design: Quasi experimental study.

Place and Duration of Study: Gynecology and Obstetrics Department of a Tertiary Care Setting, from Jan to Jun 2022.

Methodology: A total of 300 females of age >16years undergone post-Dural puncture during cesarean section were included. Patients who had any gastric illness and emergency cases were excluded. The patient population was divided into two Groups; in Group-A patients were given intra-nasal Desmopressin while Group-B patients were given normal saline. Symptoms including headache and nausea appeared after dural puncture were recorded in a pre-designed questionnaire. The study also observed the duration of symptoms relieved. Statistical analysis was done using SPSS version-24. Descriptive and inferential statistics was applied.

Results: In a sample of 300 participants, Group-A (150 patients) were given Desmopressin and 150 patients of Group-B were given normal saline. The mean age of participants was 28.9±3.8 years. Mean spinal needle gauze size was 20.8±4.1 G. In Desmopressin Group the duration of symptoms was 24hrs for 20(13.3%) patients, 37(24.7%) patients had 48hrs to recover, 47(31.3%) had 72hrs and 46(30.7%) had <7days of time for the recovery of symptoms. While in normal saline Group most of the participants 64(42.7%) took<7 days to recover. While in normal saline ..

Conclusion: Desmopressin is more beneficial than normal saline for the prevention of post dural puncture headache in patients undergoing cesarean delivery under spinal anesthesia.

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