Association of Admission Platelet Crit with In-Hospital Outcomes in Non ST-Elevation Myocardial Infarction (NSTEMI)
DOI:
https://doi.org/10.51253/pafmj.v75iSUPPL-3.12679Keywords:
In-hospital outcomes, Non-ST elevation myocardial infarction, Plateletcrit, Platelet indices.Abstract
Objective: To determine the association of admission plateletcrit with in-hospital outcomes in non ST-elevation myocardial infarction (NSTEMI).
Study Design: Analytical Cross-sectional study
Place and Duration of Study: Armed Forces Institute of Cardiology/National Institute of Heart Diseases, Rawalpindi; from Nov 2023 to Apr 2024
Methodology: Using non-probability consecutive sampling, 270 patients were included in this study. ECG findings were noted. Patients were divided into three tertiles based upon plateletcrit value such as T1=lower than normal PCT value (<0.21), T2=normal PCT(0.21-0.22) and T3= higher than normal PCT value (>0.22). PCT values were obtained from complete blood count sent at the time of presentation to AFIC emergency using Mandray BC 6200 CBC analyzer available at the AFIC pathology laboratory.
Results: The study included 270 patients, out of which 137(50.7%) were males and 133(49.3%) were females and median age was 62.00(55.00-70.00) years. T1, T2 and T3 had 71(26.3%), 34(12.6%) and 165(61.1%) patients, respectively. Significant frequency differences of hypertensive and hyperlipidemia patients, and in-hospital outcomes were found between tertiles (p<0.01). Plateletcrit value was identified as an independent predictor for in-hospital outcomes including coronary revascularization (OR=0.08, 95% CI: 0.04-1.58, p<0.01), cardiogenic shock (OR=0.24, 95% CI: 0.15-0.37, p<0.01) and mortality (OR=0.04, 95% CI: 0.02-0.11, p<0.01), when adjusted for covariates.
Conclusion: Plateletcrit value is an important predictor of in-hospital outcomes in NSTEMI patients, particularly coronary revascularization, cardiogenic shock, and mortality.
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References
Martin SS, Aday AW, Almarzooq ZI, Anderson CA, Arora P, Avery CL, et al. 2024 heart disease and stroke statistics: a report of US and global data from the American Heart Association. Circulation. 2024; 149(8): e347-913.
https://doi:10.1161/cir.0000000000001209
Özlü MF, Öztürk S, Ayhan SS, Tosun M, Alçelik A, Erdem A. Predictive value of mean platelet volume in young patients with non-ST-segment elevation acute coronary syndromes: a retrospective observational study. Ana J of Cardiol/ Anadolu Kardiyol Derg. 2013; 13(1). https://10.5152/akd.2013.007
Pogorzelska K, Krętowska A, Krawczuk-Rybak M, Sawicka-Żukowska M. Characteristics of platelet indices and their prognostic significance in selected medical condition – a systematic review. Adv Med Sci. 2020; 65(2): 310–315.
https://doi/10.1016/j.advms.2020.05.002
Pepine CJ, Nichols WW. The pathophysiology of chronic ischemic heart disease. Clinical Cardiology: An International Indexed and Peer‐Reviewed Journal for Advances in the Treatment of Cardiovasc Disease. 2007; 30(1): I-4.
https://doi/10.1002/clc.20048
Aslan S, Demir AR, Demir Y, Taşbulak Ö, Altunova M, Karakayalı M, et al. Usefulness of plateletcrit in the prediction of major adverse cardiac and cerebrovascular events in patients with carotid artery stenosis. Vascular. 2019; 27(5): 479–486.
https://doi/10.1177/1708538119847898
Huczek Z, Kochman J, Filipiak KJ, Horszczaruk GJ, Grabowski M, Piatkowski R,et al. Mean platelet volume on admission predicts impaired reperfusion and long-term mortality in acute myocardial infarction treated with primary percutaneous coronary intervention. J Am Coll Cardiol. 2005; 46(2): 284-290.
https://doi.org/10.1016/j.accreview.2005.09.010
Ali I, Shabbir M, Khan AN, Shehram M, Mekan GR, Khan IA. Correlation of serum low-density lipoprotein cholesterol with grace and TIMI scores to predict 30 days mortality following acute coronary. Pak Armed Forces Med J. 2019; 69: S425-429 https://pafmj.org/PAFMJ/article/view/3556
Keskin M, Kaya A, İpek G, Bolca O, Doğan S, Özçelik F, et al. A simple independent predictor of in-hospital and long-term outcomes in patients with STEMI: Plateletcrit. hamidiyemedj. 2020; 1(1): 22–28.
https://doi.org/10.4274/hamidiyemedj.galenos.2020.65375
Wiwanitkit V. Plateletcrit, mean platelet volume, platelet distribution width: Its expected values and correlation with parallel red blood cell parameters. Clin Appl Thromb Hemost. 2004; 10(2): 175–178. https://10.1177/107602960401000208
Gul M, Uyarel H, Akgul O, Akkaya E, Surgit O, Cakmak HA, et al. Long-term prognostic significance of admission plateletcrit values in patients with non-ST elevation myocardial infarction. Blood Coagul Fibrinolysis. 2016; 27(6): 696-701.
https://doi.org/10.1097/MBC.0000000000000484
Badimon L, Padró T, Vilahur G. Atherosclerosis, platelets and thrombosis in acute ischaemic heart disease. Eur Heart J: Acute Cardiovasc Care. 2012; 1(1): 60-74.
https://10.1177/2048872612441582
Theofilis P, Oikonomou E, Chasikidis C, Tsioufis K, Tousoulis D. Pathophysiology of acute coronary syndromes—diagnostic and treatment considerations. Life. 2023; 13(7): 1543.
https://doi.org/10.3390/life13071543
Wang H, Liu Z, Shao J, Lin L, Jiang M, Wang L et al, Immune and inflammation in acute coronary syndrome: molecular mechanisms and therapeutic implications. J Immunol Res. 2020; 2020(1): 4904217. https://doi.org/10.1155/2020/4904217
Henein MY, Vancheri S, Longo G, Vancheri F. The Role of Inflammation in Cardiovascular Disease. Int J Mol Sci. 2022 ; 23(21): 12906.https://doi.org/10.3390/ijms232112906
Ghafoor MB, Sarwar F, Bashir B, Yasmeen F, Abbasi S, Hameed Z. An Evaluation of Platelet Indices in Newly Diagnosed Cases of Acute Myocardial Infarction: Platelet Indices and Acute Myocardial Infarction. Pak J Health Sci. 2024: 126-130.
https://doi.org/10.54393/pjhs.v5i04.1449
Korniluk A, Koper-Lenkiewicz OM, Kamińska J, Kemona H, Dymicka-Piekarska V. Mean Platelet Volume (MPV): New Perspectives for an Old Marker in the Course and Prognosis of Inflammatory Conditions. Mediators Inflamm. 2019; 2019(1): 9213074.
https://doi.org/10.1155/2019/9213074
Bećirović E, Ljuca K, Bećirović M, Ljuca N, Bajrić M, Brkić A, et al. Prognostic value of a decrease in mean platelet volume, platelet distribution width, and platelet-large cell ratio for major adverse cardiovascular events after myocardial infarction without ST-segment elevation: An observational study. Biomolecules & Biomedicine. 2023 4; 23(5): 866-872. https://doi.org/10.1155/2019/9213074
Tasneem SP. Plateletcrit: A Novel Risk Predictor of Acute Myocardial Infarction. Circulation. 2023; 148(1): A13525. https://doi.org/10.1161/circ.148.suppl_1.13525
Kathrine AS, Pramantara ID, Hartopo AB. Plateletcrit as Risk Factor of Major Adverse Cardiac Event in Elderly Patient with Acute Coronary Syndrome. Acta Interna: J Internal Medicine. 2023; 12(1): 19-28.
https://doi.org/10.22146/actainterna.98161
Sudharsono A, Khairina D, Muzakkir AF, Alkatiri AH, Amir MZ. The role of plateletcrit and red blood cell distribution width as a predictor of in-hospital mortality in patients with acute coronary syndrome. Eur Heart J. 2020; 41(2): 946-1357.
https://doi.org/10.1093/ehjci/ehaa946.1357
Sharma D, Pandey M, Rishi JP. A Study of platelet volume indices in patients of coronary artery diseases. Journal Sci Innov Res. 2016; 5(5): 161-164.
http://dx.doi.org/10.31254/jsir.2016.5501
Małyszczak A, Łukawska A, Dyląg I, Lis W, Mysiak A, Kuliczkowski W. Blood platelet count at hospital admission impacts long-term mortality in patients with acute coronary syndrome. Cardiol. 2020; 145(3): 148-154.
https://doi.org/10.1159/000505640
Wasilewski, J., Desperak, P., Hawranek, M., Ciślak, A., Osadnik, T., Pyka, Ł., et al. Prognostic implications of mean platelet volume on short-and long-term outcomes among patients with non-ST-segment elevation myocardial infarction treated with percutaneous coronary intervention: a single-center large observational study. Platelets. 2016; 27(5), 452-548.
https://doi.org/10.3109/09537104.2016.1143919
Khode V, Sindhur J, Kanbur D, Ruikar K, Nallulwar S. Mean platelet volume and other platelet volume indices in patients with stable coronary artery disease and acute myocardial infarction: A case control study. J Cardiovasc Dis Res. 2012; 3(4): 272-275. https://doi.org/10.4103/0975-3583.102694
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