Open Access Original Article  Reduction of Dentine Hypersensitivity after Non-Surgical Periodontal Therapy Comparing 5% Calcium Sodium Phosphosilicate and 8% Arginine Dentifrices: A Single Centre Randomized Controlled Trial

Muhammad Junaid Iqbal; Sharjeel  Ashraf; Yasir Ikram Ahmed; Anis Rehman; Ahmed Abdullah; Raheel Ahmed

doi:10.51253/pafmj.v76iSUPPL-7.12622

Authors

Muhammad Junaid Iqbal Department of Periodontology, Armed Forces Institute of Dentistry, Rawalpindi /National University of Medical Sciences (NUMS) Pakistan
Muhammad Sharjeel Ashraf Department of Periodontology, Armed Forces Institute of Dentistry, Rawalpindi /National University of Medical Sciences (NUMS) Pakistan
Yasir Ikram Ahmed Department of Periodontology, Armed Forces Institute of Dentistry, Rawalpindi /National University of Medical Sciences (NUMS) Pakistan
Anis-ur-Rehman Department of Periodontology, Armed Forces Institute of Dentistry, Rawalpindi /National University of Medical Sciences (NUMS) Pakistan
Ahmed Abdullah Department of Periodontology, Armed Forces Institute of Dentistry, Rawalpindi /National University of Medical Sciences (NUMS) Pakistan
Raheel Ahmed Department of Periodontology, Armed Forces Institute of Dentistry, Rawalpindi /National University of Medical Sciences (NUMS) Pakistan

DOI:

https://doi.org/10.51253/pafmj.v76iSUPPL-7.12622

Keywords:

Dentifrice, Dentin Hypersensitivity, Desensitizing Agents, Randomized Controlled Trial, Periodontitis

Abstract

Objective: To evaluate the effectiveness of 8% arginine and 5% Calcium Sodium Phosphosilicate (CSPS) as desensitizing agents to provide relief against Dentine Hypersensitivity (DH).

Study Design: Randomized controlled study (ClinicalTrials.gov ID: NCT06273930).

Place and Duration of Study: Department of Periodontology, Armed Forces Institute of Dentistry, Rawalpindi, Pakistan, from Feb to Aug 2024.

Methodology: The study included eighty-seven subjects with chronic periodontitis and were allocated into three groups (Group-A: control, Group-B: CSPS and Group-C: arginine) in a ratio of 1:1:1. Participants were provided with dental care instructions to brush twice daily using only the dentifrice containing toothpaste. Each subject’s score was recorded by averaging the three Schiff and VAS score values. The data was recorded at baseline, immediate in-office application, 1-, 2- and 4-week time, and Kruskal-Wallis and Mann-Whitney-U tests were applied.

Results: The Schiff and VAS score analysis indicated that a significant difference was observed among patients using dentifrice with 8% arginine, and 5% CSPS compared to control (p<0.001). Both groups B and C had mean DH reduction observed at in-office application and the following weeks. With 83.7% in CSPS, 78.9% in Group-C, and 63.9% in Group-A, week 4 produced the largest percentage mean DH reduction in Schiff score. Less than 50% of patients with DH were observed in groups B and C with CSPS after the first week.

Conclusion: Efficacy of Calcium Sodium Phosphosilicate (CSPS) and arginine as desensitizing agents was explored and its effects in reducing Dentine Hypersensitivity (DH) in patients with periodontitis was confirmed.

Downloads

Download data is not yet available.

References

1. Mohammadipour HS, Bagheri H, Babazadeh S, Khorshid M, Shooshtari Z, Shahri A. Evaluation and comparison of the effects of a new paste containing 8% L-Arginine and CaCO3 plus KNO3 on dentinal tubules occlusion and dental sensitivity: a randomized, triple blinded clinical trial study. BMC Oral Health 2024; 24(1): 507. https://doi.org/10.1186/s12903-024-04298-3

2. Liu XX, Tenenbaum HC, Wilder RS, Quock R, Hewlett ER, Ren YF. Pathogenesis, diagnosis and management of dentin hypersensitivity: an evidence-based overview for dental practitioners. BMC Oral Health 2020; 20(1).

https://doi.org/10.1186/s12903-020-01147-9

3. Goldstein R, Auclair Clark W. The clinical management of awake bruxism. J Am Dent Assoc 2017; 148(7): 387–391.

https://doi.org/10.1016/j.adaj.2017.03.005

4. Miglani S, Aggarwal V, Ahuja B. Dentin hypersensitivity: recent trends in management. J Conserv Dent 2010; 13(4): 218-224.

https://doi.org/10.4103/0972-0707.73385

5. Dam VV, Nguyen TH, Trinh HA, Dung DT, Hai TD. Advances in the management of dentin hypersensitivity: an updated review. Open Dent J 2022; 16(1).

http://dx.doi.org/10.2174/18742106-v16-e2201130

6. Zhou Z, Yang Z, Wang F, Lu K, Li Y. Arginine-containing desensitizing toothpaste for the treatment of dentin hypersensitivity: a meta-analysis. Clin Cosmet Investig Dent 2016; 8(1): 1-14. https://doi.org/10.2147/CCIDE.S95660

7. Dionysopoulos D, Gerasimidou O, Beltes C. Dentin hypersensitivity: etiology, diagnosis and contemporary therapeutic approaches—a review in literature. App Sci 2023; 13(21): 11632. https://doi.org/10.3390/app132111632

8. Mason S, Kingston R, Shneyer L, Harding M. Clinical study to monitor dentinal hypersensitivity with episodic use of a desensitising dentifrice. BDJ Open 2017; 3(1): 17011.

https://doi.org/10.1038/bdjopen.2017.11

9. Creeth J, Goyal CR, Qiu J, Lamptey M, Sanchez E, Qaqish J, et al. Time-course of clinical efficacy of a 5% calcium-sodium phosphosilicate toothpaste on dentine hypersensitivity. J Dent 2026: 106710.

https://doi.org/10.1016/j.jdent.2026.106710

10. Kar P, Shaikh Z, Hiremath A, Vikneshan M. Comparison of the effectiveness of three different desensitizing toothpastes in reducing dentin hypersensitivity: a 4-week clinical study. J Conserv Dent 2019; 22(2): 181.

https://doi.org/10.4103/JCD.JCD_304_18

11. Freda NM, Veitz-Keenan A. Calcium sodium phosphosilicate had some benefit on dentine hypersensitivity. Evid Based Dent 2016; 17(1): 12–13. https://doi.org/10.1038/sj.ebd.6401148

12. Zhu M, Li J, Chen B, Mei L, Yao L, Tian J, et al. The effect of calcium sodium phosphosilicate on dentin hypersensitivity: a systematic review and meta-analysis. PLOS One 2015; 10(11): e0140176. https://doi.org/10.1371/journal.pone.0140176

13. Ziaaddini S, Riahi N, Majidinia S, Sarraf Shirazi A, Motamedosanaye V, Mostafazadehbakhtiyary M. Calcium sodium phosphosilicate toothpastes impact on the treatment of dentin hypersensitivity: an umbrella review. Saudi Dent J 2025; 37(10): 1-3. https://doi.org/10.1007/s44445-025-00079-y

14. Uraz A, Erol-Simsek O, Pehlivan S, Suludere Z, Bal B. The efficacy of 8% arginine-CaCO3 applications on dentine hypersensitivity following periodontal therapy: a clinical and scanning electron microscopic study. Med Oral Patol Oral Cir Bucal 2013; e298–305.

https://doi.org/10.4317/medoral.17990

15. Ongphichetmetha N, Lertpimonchai A, Champaiboon C. Bioactive glass and arginine dentifrices immediately relieved dentine hypersensitivity following non‐surgical periodontal therapy: a randomized controlled trial. J Periodontol 2021; 93(2): 248-257. https://doi.org/10.1002/JPER.21-0091

16. Champaiboon C, Lertpimonchai A, Lertpimonchai K. Bioactive glass versus arginine dentifrices on the reduction of dentin permeability and acid tolerance. Clin Exp Dent Res 2020; 7(4): 620–627. https://doi.org/10.1002/cre2.372

17. Ramadoss R, Padmanabhan R. Calcium Sodium Phosphosilicate in Management of Dentin Hypersensitivity and Strategies for Reconstitution of the Dentin Matrix. J Biomed Mater Res App Biomater 2025; 113(4): e35576.

https://doi.org/10.1002/jbm.b.35576

18. Al-Haddad A, Alarami N, Alshammari AF, Madfa AA. Efficacy of bioactive glass-based desensitizer compared to other desensitizing agents or techniques in dentin hypersensitivity: a systematic review. BMC Oral Health 2025; 25(1): 899.

https://doi.org/10.1186/s12903-025-06288-5

19. Destro JM, Reis BD, Chrisostomo DA, Strazzi-Sahyon HB, Queiroz ME, Benetti F, et al. Comparative Effects of Experimental Bioactive Glasses on Dentin Permeability and Tubule Occlusion In Vitro. J Funct Biomater 2026; 17(6): 302.

https://doi.org/10.3390/jfb17060302