Therapeutic Role of Intratympanic Platelet Rich Plasma with Steroid in Sensorineural Hearing Loss and Tinnitus

Maryam iftikhar; Farhan Akbar; Noman Karim; Umer Younas

doi:10.51253/pafmj.v76iSUPPL-3.12596

Authors

Maryam iftikhar Department of ENT, Combined Military Hospital Hyderabad/National University of Medical Sciences (NUMS) Pakistan
Farhan Akbar Department of ENT, Combined Military Hospital Hyderabad/National University of Medical Sciences (NUMS) Pakistan
Noman Karim Department of ENT, Combined Military Hospital Hyderabad/National University of Medical Sciences (NUMS) Pakistan
Umer Younas Department of Rehab Medicine, Combined Military Hospital Hyderabad/National University of Medical Sciences (NUMS) Pakistan

DOI:

https://doi.org/10.51253/pafmj.v76iSUPPL-3.12596

Keywords:

Platelet-Rich Plasma, Sensorineural Hearing Loss, Tinnitus

Abstract

Objective: To observe the curative effects of intratympanic injection of platelet-rich plasma and steroids on sensorineural hearing loss and tinnitus, in order to achieve audiometric gain and symptomatic relief respectively.

Study Design: Prospective longitudinal study.

Place and Duration of Study: Combined Military Hospital, Hyderabad Pakistan, from Dec 2022 to Dec 2023.

Methodology: A total of 60 patients were selected. One ml of platelet-rich plasma (PRP) with steroid was injected through tympanic membrane. Three sessions were performed 6 weeks apart. Degree of hearing loss and its recovery as complete, partial and no recovery was recorded using pure-tone audiometry before and after the therapy. Similarly, tinnitus handicap inventory questionnaire was filled to observe the grades of tinnitus, handicap levels and improvement of symptoms. Chi square test and Mann-Whittney U-test were applied.

Results: Out of 60 patients, 38(63.3%) were male and 22(36.7%) female. Mean age was 39.18±16.44 years. Median of pretreatment scoring of tinnitus was 37.00 (49.25–18.00) and post treatment 10.50 (22.50–0.00). There was significant difference pre and post treatment as (p<0.001). After three sessions of PRP therapy, the distribution of hearing improvement across degrees of hearing loss was statistically significant (p=0.004), indicating a meaningful effect of PRP therapy on hearing outcomes.

Conclusion: We concluded that introducing regenerative intratympanic PRP therapy in ENT is highly effective and shows significant improvement in sensorineural hearing loss and tinnitus due to release of growth factors, nerve regeneration and its natural healing process.

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