Efficacy of Half Dose and One Third Dose of Injection Taurolock® for Tunneled Double  Lumen Catheter Lock Solution

Ghulam  Mustafa; Nauman  Kashif; Sohail  Sabir; Farrukh  Islam; Ruqaiyya  Nazir; Muhammad  Iqbal

doi:10.51253/pafmj.v75iSUPPL-6.12594

Authors

Ghulam Mustafa Department of Nephrology, Armed Forces Institute of Urology, Rawalpindi/National University of Medical Sciences (NUMS) Pakistan
Nauman Kashif Department of Nephrology, Armed Forces Institute of Urology, Rawalpindi/National University of Medical Sciences (NUMS) Pakistan
Sohail Sabir Department of Nephrology, Pak Emirates Military Hospital, Rawalpindi/National University of Medical Sciences (NUMS) Pakistan
Farrukh Islam Department of Nephrology, Armed Forces Institute of Urology, Rawalpindi/National University of Medical Sciences (NUMS) Pakistan
Ruqaiyya Nazir Department of Physiology, Islamic International Medical College, Rawalpindi Pakistan
Muhammad Iqbal Department of General Medicine, Pak Emirates Military Hospital, Rawalpindi/National University of Medical Sciences (NUMS) Pakistan

DOI:

https://doi.org/10.51253/pafmj.v75iSUPPL-6.12594

Keywords:

Catheter Related Infection, Hemodialysis, Taurolidine

Abstract

Objective: To compare the efficacy of TaurolockHEP500®, as half and one third of standard dose on prevention of catheter related blood stream infection (CRBSI) and catheter dysfunction in patients undergoing hemodialysis via tunneled double lumen catheter.

Study Design: Quasi-experimental study.

Place and Duration of Study: Department of Nephrology, Armed Forces Institute of Urology, Rawalpindi, Pakistan, and Pak Emirates Military Hospital Rawalpindi, Pakistan from Sep, 2023 to Apr, 2024.

Methodology: The study recruited 314 patients, were divided into two groups; Group-A (n=157) and Group-B (n=157). Injection TaurolockHEP500® was administered into the tunneled double lumen catheter as half doses for Group-A and one third doses for Group-B. The rest of the space in catheter’s lumen was filled with heparin. All the patients were then followed for 3 months. Blood samples for culture and sensitivity, were taken from both ports of their tunneled catheters and from a peripheral vein simultaneously to confirm CRBSI during fever spike in hemodialysis. Moreover, blood flow rates were monitored during each session to detect catheter dysfunction.

Results: Catheter function and blood culture didn’t show a significant difference among two study groups (Group-A and Group-B) with p-values 0.702 and 0.556 respectively.

Conclusion: The catheter lock solution TaurolockHEP500® even in one third dose, after each session of hemodialysis, can significantly reduce the rate of bacteremia and catheter dysfunction.

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