EFFICACY OF DYDROGESTERONE IN THE MANAGEMENT OF THREATENED MISCARRIAGE IN THE FIRST TRIMESTER

Abstract

 To study the efficacy d dydrogesterone in pregnant women with threatened miscarriage in the first trimester. Study design: Randomized control trial. Place and duration of study Department of Obstetrics and Gynaecology. Military Hittite] itawalpindo from an 20fkO to Dec 2005. Patients and Methods: One hundred and fifty two pregnant women presenting to the Gynae and Ot.. department (MU Rwp) before 12th gestational week were selected on the basis of slight pain or vaginal bkocding. no cervical dilatation and a viable pregnancy on ultrasound. They were divided randomly into two groups each containing 76 patients with the trip of simple random number table, after obtaining their consent and explaining all the risks and benefits to them Bias was controlled by double blinding. Patients in group A reeved oral ilydroonsterone (10mg twice daily) and patients in group B received placebo. Treatment was continued till the 12th gestational week and pant ms wen. followed up 4 weekly after the completion of treatment till the Mb gestational week Improvement was judged by continuation al pregnancy and remittance of symptoms. 
Results: Patients in group A had a greater improvement in the symptoms of pain and vaginal bleeding but the difference between the two group; was not statistically significant. However the number of patients who had a normal growth and whose pregnancies continued was significantly higher in group A. Coseliteienc It was concluded that the continuing pregnancy success rate was significantly higher In women treated with dydrogestenne compared with women who received placebo treatment.