Role of Mentzer Index (Mi) In Screening Iron Deficiency Anemia (Ida) In Children At Tertiary Care Hospital
DOI:
https://doi.org/10.51253/pafmj.v76iSUPPL-6.12036Keywords:
Anemia, Ferritin, Iron Deficiency, Mentzer Index, ScreeningAbstract
Objective: To verify the significance of the Mentzer index as a method of screening Iron deficiency anemia (IDA) in preschool children.
Study Design: Analytical cross-sectional study.
Place and Duration of Study: Combined Military Hospital (CMH), Rawalpindi, Pakistan, from Aug 2023 to Feb 2024.
Methodology: Using non-probability consecutive sampling, 358 children presenting to the Emergency Department (ED) and Outpatient Department (OPD) were included. Anemia in preschoolers (3–5 years old) was identified using World Health Organization (WHO) criteria. The Mentzer index (MI) was calculated for each participant. Samples were collected for serum ferritin levels, to confirm the diagnosis of IDA.
Results: The mean age of participants in our study was 3.97±0.88 years. Of the 358 participants, 187 were females (52.20%) and 171 were males (47.80%). The mean hemoglobin level was 9.06±1.16g/dl, the Red Blood Cell (RBC) count was 5.02±0.808 x106/µL, the Mean Corpuscular Volume (MCV) was 64.10±8.61 fL, the hematocrit level (HCT) was 28.79±2.82% and the average serum ferritin level was 12.57±10.28 µg/l. The results of the validation statistical model were obtained including sensitivity (88.14%), specificity (84.43%), Positive Predictive Value (91.67%), Negative Predictive Value (78.63%), and diagnostic accuracy (86.87%).
Conclusion: The Mentzer Index exhibits satisfactory validation statistics, including diagnostic accuracy, sensitivity, specificity, and NPV, making it a reliable screening tool for IDA.
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References
1. World Health Organization. Anemia in women and children [Internet]. Available from: https://www.who.int/data/gho/data/themes/topics/anaemia_in_women_and_children
2. Institute for Health Metrics and Evaluation. Anemia - Level 1 impairment [Internet]. Available from: https://www.healthdata.org/research-analysis/diseases-injuries/factsheets/anemia-level-1-impairment
3. Adam H. Screening for anemia. In: Point-of-Care Quick Reference. American Academy of Pediatrics; 2020.
https://doi.org/10.1542/aap.ppcqr.396021
4. Özdemir N. Iron deficiency anemia from diagnosis to treatment in children. Turk Arch Pediatr. 2015; 50(1): 11-19.
https://doi.org/10.5152/tpa.2015.2337
5. Kumar A, Sharma E, Marley A, Samaan MA, Brookes MJ. Iron deficiency anaemia: pathophysiology, assessment, practical management. BMJ Open Gastroenterol. 2022; 9(1): e000759.
https://doi.org/10.1136/bmjgast-2021-000759
6. Wing N, editor. Ministry of National Health Services, Regulations and Coordination, Government of Pakistan. Pakistan National Nutrition Survey 2018. Government of Pakistan; 2018.
7. Vehapoglu A, Ozgurhan G, Demir AD, Uzuner S, Nursoy MA, Turkmen S, et al. Hematological indices for differential diagnosis of beta thalassemia trait and iron deficiency anemia. Anemia. 2014; 2014: 576738.
https://doi.org/10.1155/2014/576738
8. Mentzer WC. Differentiation of iron deficiency from thalassaemia trait. Lancet. 1973; 301(7808): 882.
https://doi.org/10.1016/S0140-6736(73)91446-3
9. Tabassum S, Khakwani M, Fayyaz A, Taj N. Role of Mentzer index for differentiating iron deficiency anemia and beta thalassemia trait in pregnant women. Pak J Med Sci. 2022; 38(4 Pt 2): 878-882.
https://doi.org/10.12669/pjms.38.4.4635
10. Bogen DL, Duggan AK, Dover GJ, Wilson MH. Screening for iron deficiency anemia by dietary history in a high-risk population. Pediatrics. 2000; 105(6): 1254-2159.
https://doi.org/10.1542/peds.105.6.1254
11. Jahangiri M, Rahim F, Malehi AS. Diagnostic performance of hematological discrimination indices to discriminate between beta thalassemia trait and iron deficiency anemia and using cluster analysis: introducing two new indices tested in Iranian population. Sci Rep. 2019; 9: 18610.
https://doi.org/10.1038/s41598-019-54575-3
12. Alam SLS, Purnamasari R, Bahar E, Rahadiyanto KY. Mentzer index as a screening tool for iron deficiency anemia in 6-12-year-old children. Paediatr Indones. 2014; 54(5): 294-298.
13. Amer J. A retrospective study using Mentzer index for prevalence of iron deficiency anemia among infants visiting maternal centers at the age of one year. Anemia. 2022; 2022: 7236317. https://doi.org/10.1155/2022/7236317
14. Sherali A, Ahad A, Tikmani SS, Sohail S. Screening of iron deficiency anemia in children using Mentzer index in Pakistan: a cross sectional study. Glob Pediatr Health. 2023; 10: 2333794X221130986. https://doi.org/10.1177/2333794X221130986
15. Awais M, Ahmad A, Farid A, Khan H. Mentzer index as a screening tool for iron deficiency anemia in 6-12 years old children. J Postgrad Med Inst. 2022; 36(4): 235-238. https://doi.org/10.54079/jpmi.36.4.3099
16. Ahmed HS, Hashem EA, Al-asheer OM, Mahmoud AA. The diagnostic performance of red cell distribution width and Mentzer index for discrimination between iron deficiency anemia and beta thalassemia trait. Med J Cairo Univ. 2018; 86(7): 3979-3988.
https://doi.org/10.21608/mjcu.2018.62193
17. Zulqarnain H, Nadeem MT, Shahid H, Mujtaba A, Ikram F, Arshad Z. Validity of Mentzer index in predicting iron deficiency anaemia. Pak Armed Forces Med J. 2024; 74(1): 63-66. https://doi.org/10.51253/pafmj.v74i1.8761
18. Gao J, Liu W. Advances in screening of thalassaemia. Clinica Chimica Acta. 2022 1; 534: 176-184.
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