Association of Triglyceride-Glucose (TyG) Index with Diabetic Nephropathy (DN) In Patients of Type II Diabetes Mellitus Presenting in Primary Clinics

Simra Tanveer; Sadaf  Nawaz; Aftab Ali  Kalroo; Athar Iqbal  Paracha; Namra  Nazir; Hadia  Tahir

doi:10.51253/pafmj.v76iSUPPL-6.11760

Authors

Simra Tanveer Department of Family Medicine, Pak Emirates Military Hospital/National University of Medical Sciences (NUMS), Rawalpindi Pakistan
Sadaf Nawaz Department of Family Medicine, Pak Emirates Military Hospital/National University of Medical Sciences (NUMS), Rawalpindi Pakistan
Aftab Ali Kalroo Department of Health Care Administrator, Forward Treatment Centre, 4 Medical Battalion, Pakistan
Athar Iqbal Paracha Department of Chemical Pathology, Forward Treatment Centre, 4 Medical Battalion, Pakistan
Namra Nazir Department of Family Medicine, Pak Emirates Military Hospital/National University of Medical Sciences (NUMS), Rawalpindi Pakistan
Hadia Tahir Department of Family Medicine, Pak Emirates Military Hospital/National University of Medical Sciences (NUMS), Rawalpindi Pakistan

DOI:

https://doi.org/10.51253/pafmj.v76iSUPPL-6.11760

Keywords:

Diabetic Nephropathy, Insulin Resistance, Triglyceride Glucose Index, Type II DM

Abstract

Objective: To determine the association of triglyceride-glucose (TyG) index with diabetic nephropathy (DN) in patients with type II diabetes mellitus presenting in primary clinics

Study Design: Cross-sectional study.

Place and Duration of Study: Department of Family Medicine, Pak Emirates Military Hospital, Rawalpindi Pakistan, from Oct 2023 to Jan 2024.

Methodology: Patients aged between 25 and 60 years, known cases of Type 2 DM, oral hypoglycemics, and reporting to family medicine clinic for their follow-up were included. Samples of 231 patients were collected for serum triglyceride, fasting plasma glucose, and urinary ACR. Patients were divided into DN and non-DN groups based on urinary ACR (cut off <30 mg/g). The TyG index was compared between the two groups. Correlation and association were determined between the TyG index and DN.

Results: DN was detected in 48(20.8%) patients while 183(79.2%) were non-DN. Patients with DN had a greater TyG index as compared to those without DN (8.13±0.46 vs 7.19±0.33), and the difference was statistically significant (p-value <0.001). Correlation studies revealed a positive linear correlation of urinary ACR levels with serum triglyceride (r =0.898, p-value <0.01) and an association study of TyG index with DN revealed OR 1.89 (95% CI 1.38 - 2.35) p<0.001.

Conclusion: TyG index is greater in patients with DN as compared to non-DN. TyG index, being a low-cost and routinely available test, has the potential to be used as a risk assessment and early detection tool for DN.

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