Hematological Parameters and Coagulation Profile in Patients with Chronic Liver Disease and its Correlation with Disease Severity

Abstract

Objective: To determine the haematological parameters and coagulation profile in patients with Chronic Liver Disease and to
study their correlation with disease severity.

Study Design: Cross sectional study.

Place and Duration of Study: Department of Gastroenterology, Pak Emirates Military Hospital, Rawalpindi Pakistan and
Department of Haematology, Armed Forces Institute of Pathology, Rawalpindi Pakistan, from Sep 2017 to Aug 2018.

Methodology: Hundred and eighty patients diagnosed with chronic liver disease were included in the study and compared
with 60 normal healthy age and sex matched individuals. Haematologic parameters were assessed by automated haematology
analyzer, peripheral blood films examined and coagulation studies were performed. These parameters were studied in
association with disease severity.

Results: A total of 180 cases of Chronic Liver Disease were analyzed. Median age of patients was 42 years with a male to
female ratio of 2.2:1. Anaemia and thrombocytopenia were prominently seen in chronic liver disease. The haemoglobin level
and platelet count significantly decreased with increasing severity of disease. Prothrombin time and activated partial
thromboplastin time were prolonged in majority of patients.

Conclusion: Haematologic parameters and coagulation profile are cost effective methods for assessing severity of chronic liver
disease and monitoring for complications and prognosis