Recurrent Pregnancy Loss in Women with Asymptomatic Sjogren's Syndrome - A Rare Case Reported from Pakistan

Muhammad Zain Arshad; Maymoona Suhail; Dawood Ahmad; Ayesha Tanveer; Yumna Rubab; Hamid Saeed Malik

doi:10.51253/pafmj.v75iSUPPL-7.10059

Authors

Muhammad Zain Arshad Department of Immunology, Armed Forces Institute of Pathology/National University of Medical Sciences (NUMS), Rawalpindi Pakistan
Maymoona Suhail Department of Hematology, Armed Forces Institute of Pathology/National University of Medical Sciences (NUMS), Rawalpindi Pakistan
Dawood Ahmad Department of Immunology, Armed Forces Institute of Pathology/National University of Medical Sciences (NUMS), Rawalpindi Pakistan
Ayesha Tanveer Department of Hematology, Armed Forces Institute of Pathology/National University of Medical Sciences (NUMS), Rawalpindi Pakistan
Yumna Rubab Department of Diagnostic Radiology, Combined Military Hospital/National University of Medical Sciences (NUMS), Rawalpindi Pakistan
Hamid Saeed Malik Department of Hematology, Armed Forces Institute of Pathology/National University of Medical Sciences (NUMS), Rawalpindi Pakistan

DOI:

https://doi.org/10.51253/pafmj.v75iSUPPL-7.10059

Keywords:

Autoantibodies, Recurrent Miscarriages, Sjogren's Syndrome

Abstract

Sjogren's syndrome is systemic autoimmune disorder affecting multiple systems. It predominantly affects females and is characterized by dryness of eyes and mouth. It is association with pregnancy may result in Neonatal Lupus presenting prenatally, postnatally or both. Complications may include congenital heart block (CHB), cutaneous lesions and hematological abnormalities. Usually, titre of anti Ro/SS-A and anti La/SS-B antibodies in maternal serum are proportional to fetal outcomes. However, these antibodies can affect fetus even in asymptomatic mothers. We hereby report the first case of an adult female with asymptomatic Primary Sjogren's syndrome, presenting with recurrent miscarriages due to trans-placental passage of auto-antibodies resulting in CHB. Knowledge of this disorder can help in early diagnosis and prevention of pregnancy associated morbidity and mortality.

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