Sol Brain, Pre-Operative Magnetic Resonance Spectroscopy and Surgical Biopsy Yield

Khurshid Ali Bangash; Nasrin Yousaf; Sohail Ilyas; Rashid Mahmood; Ishrat Parveen; Ajmal Yousaf; Arshad Khushdil; Sharoon Nathaniel

doi:10.51253/pafmj.v73i2.9503

Authors

Khurshid Ali Bangash Combined Military Hospital, Quetta/National University of Medical Sciences (NUMS) Pakistan
Nasrin Yousaf Combined Military Hospital/National University of Medical Sciences (NUMS), Rawalpindi Pakistan
Sohail Ilyas Combined Military Hospital, Quetta/National University of Medical Sciences (NUMS) Pakistan
Rashid Mahmood Combined Military Hospital, Sialkot/National University of Medical Sciences (NUMS) Pakistan
Ishrat Parveen Combined Military Hospital/National University of Medical Sciences (NUMS), Rawalpindi Pakistan
Ajmal Yousaf Combined Military Hospital/National University of Medical Sciences (NUMS), Rawalpindi Pakistan
Arshad Khushdil Combined Military Hospital, Quetta/National University of Medical Sciences (NUMS) Pakistan
Sharoon Nathaniel Combined Military Hospital, Quetta/National University of Medical Sciences (NUMS) Pakistan

DOI:

https://doi.org/10.51253/pafmj.v73i2.9503

Keywords:

Brain, Histopathology, Magnetic resonance spectroscopy, Tumour

Abstract

Objective: To ascertain the positive predictive value (PPV) of magnetic resonance spectroscopy (MRS) in diagnosing neoplastic intracranial masses by taking histopathology as a benchmark.

Study Design: Cross-sectional study.

Place and Duration of Study: Combined Military Hospital, Rawalpindi Pakistan, from Jan 2019 to Jun 2021.

Methodology: After approval from the Ethical Review Committee, 64 patients with neoplastic intracranial mass lesions on MRI were incorporated into the study. Patients with a history of brain surgery done previously, breastfeeding females, claustrophobia, already diagnosed type of tumour, and contraindication to MRI were excluded. MR Spectroscopy was performed, and findings were correlated with histopathology.

Results: Of 64 patients, 39(60.94%) were males, and 25(39.06%) were females. Magnetic Resonance Spectroscopy (MRS) supported the diagnosis of neoplastic brain lesions in all 64 patients. Histopathology confirmed malignant brain lesions in 59 cases, whereas 05 cases had benign lesions. PPV of MRS in the diagnosis of neoplastic brain lesions was 92.19%.

Conclusion: This study concluded that MRS is a non-invasive option having a very good PPV in determining neoplastic brain lesions.