Association of Hypertension with Raised Serum Homocysteine Levels

  • Hasan Ikram Army Medical College/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Syed Raza Jaffar Armed Forces Institute of Pathology/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Asma Hayat Combined Military Hospital Jehlum/National University of Medical Sciences (NUMS) Pakistan
  • Mehnaz Kahttak Fuji Foundation Hospital, Rawalpindi Pakistan
  • Ayesha Ellahi Army Medical College/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Afnan Naeem Army Medical College/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
Keywords: Diastolic pressure, Hyper-homocysteinemia, Hypertension, Systolic pressure

Abstract

Objective: To study the association of hypertension with raised serum homocysteine levels.

Study Design: Comparative cross-sectional study.

Place and Duration of Study: Army Medical College Rawalpindi in collaboration with Armed Forces Institute of Pathology and Military Hospital Rawalpindi, from Mar to May 2021.

Methodology: Total study participants were four hundred in number. Two hundred patients with hypertension aged between 35-55 years were included in Group-1, whereas two hundred non-hypertensive patients with the closest possible age and sex matching were included in Group-2. Strict adherence to inclusion and exclusion criteria was ensured.

Results: The mean age of patients with hypertension (Group 1) was 42.60 ± 9.95 years, and without hypertension, i.e., healthy participants (Group 2), was 42.26 ± 10.03 years. Systolic BP was 157.92 ± 8.07 mmHg among Group 1 (hypertensive subjects) and 114.60 ± 4.58 mmHg among Group 2 (healthy participants). Mean diastolic blood pressure in patients with hypertension (Group 1) was 104.95 ± 5.87 mmHg, whereas it was 74.20 ± 4.74 mmHg among non-hypertensive healthy participants (Group 2). Mean serum homocysteine level was significantly correlated with hypertension (p-value <0.001, r=0.804 for systolic and p-value <0.001, r=0.792 for diastolic blood pressure) and was higher in Group 1(20.64 ± 4.40 µmol/L) than that of healthy Group 2(9.48 ± 2.38 µmol/L).

Conclusion: Our study concludes that serum homocysteine had a significant positive correlation with hypertension and can be used as an early marker for hypertension assessment in addition to regular blood pressure measurements.

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Published
2022-07-28
How to Cite
Ikram, H., Jaffar, S., Hayat, A., Kahttak, M., Ellahi, A., & Naeem, A. (2022). Association of Hypertension with Raised Serum Homocysteine Levels. PAFMJ, 72(3), 1125-29. https://doi.org/10.51253/pafmj.v72i3.7219
Section
Original Articles

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