Therapeutic Efficacy of Topical Olopatadine 0.1% Versus Ketotifen Fumarate in Allergic Conjunctivitis

  • Farooq Ul Abidin Armed Forces Institute of Opthamology/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Muhammad Haroon Sarfraz POF Hospital Wah Pakistan
  • Hassaan Javaid Combined Military Hospital Peshawar/National University of Medical Sciences (NUMS) Pakistan
  • Asfandyar Khan Armed Forces Institute of Opthamology/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Summaya Khan HITEC Institute of Medical Sciences, Taxila/National University of Medical Sciences (NUMS) Pakistan
  • Haroon Javaid HITEC Institute of Medical Sciences, Taxila/National University of Medical Sciences (NUMS) Pakistan
Keywords: Allergic conjunctivitis, Efficacy, Ketotifen fumarate, Olopatadine 0.1%

Abstract

Objective: To compare the therapeutic efficacy of topical Olopatadine 0.1% versus Ketotifen Fumarate among the patients diagnosed with allergic conjunctivitis at Armed forces institute of ophthalmology.

Study Design: Prospective comparative study.

Place and Duration of Study: Armed forces Institute of Ophthalmology, Rawalpindi, from Jan 2020 to Jan 2021.

Methodology: Patients diagnosed with allergic conjunctivitis by consultant ophthalmologist fulfilling the exclusion/inclusion criteria were included in the study. They were divided into two groups by block randomization with group A receiving Olopatadine 0.1%, while group B just received the Ketotifen Fumarate. Symptoms were assessed on a symptom severity score upon diagnosis before the start of medication and then after 72 hours of treatment by a different consultant ophthalmologist who was unaware of the group of patients.

Results: A total of 100 patients were included in each group. The mean age of the study participants was 30.944 ± 3.349 years. 148 (74%) patients were males while 52 (26%) were females. The difference in mean score of symptoms in group A was 5.76 ± 1.39 while in group B was 3.33 ± 2.51. Application of t-test revealed that topical Olopatadine 0.1% was superior to Ketotifen Fumarate in reducing the symptoms of acute allergic conjunctivitis on the third day of treatment (p-value<0.001).

Conclusion: Seasonal allergic conjunctivitis was the commonest type of allergic conjunctivitis seen in our study participants. Topical Olopatadine 0.1% emerged as a better treatment option when compared to Ketotifen Fumarate for immediate management of acute allergic conjunctivitis among patients managed at a tertiary...................

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Published
2022-02-28
How to Cite
Abidin, F., Sarfraz, M., Javaid, H., Khan, A., Khan, S., & Javaid, H. (2022). Therapeutic Efficacy of Topical Olopatadine 0.1% Versus Ketotifen Fumarate in Allergic Conjunctivitis. Pakistan Armed Forces Medical Journal (PAFMJ), 72(1), 16-19. https://doi.org/10.51253/pafmj.v72i1.6324
Section
Original Articles