THE EFFICACY OF PLASMA EXCHANGE IN COVID-19 PATIENTS WITH COMORBID DIABETES MELLITUS

Plasma Exchange Efficacy in COVID-19 Patients

  • Komal Arshad Pak Emirates Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Zill-e-Humayun . Pak Emirates Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Sultan Mehmood Kamran Pak Emirates Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Ikram Khaliq Pak Emirates Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Muhammad Raza Asif Pak Emirates Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Saman Tanveer Pak Emirates Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
Keywords: COVID-19, Diabetes, Mortality rate therapeutic plasma exchange

Abstract

Objective: To explore the use of therapeutic plasma exchange as adjunctive therapy in COVID-19 patients with and without diabetes mellitus.

Study Design: Prospective, observational study.

Place and Duration of Study: Pakistan Emirates Military Hospital Rawalpindi, from Jan to Feb 2021.

Methodology: A total of 90 male patients with laboratory-confirmed coronavirus infection were selected based on our inclusion criteria and their management and outcomes were recorded. The data were analyzed using SPSS-22 and Microsoft Excel.

Results: The mortality rate was lower in patients who received 1 or more sessions of plasma exchange compared to those who did not receive plasma exchange (7.5% vs 12%). A lower mortality rate was seen in patients without diabetes who received therapeutic plasma exchange in addition to standard therapy compared to patients who received standard therapy alone (0 vs 14.82%, p=0.112). In patients with diabetes, a higher mortality rate was found in the group that had received therapeutic plasma exchange in addition to standard therapy instead of standard therapy alone (20% vs 8.7%, p=0.365).

Conclusion: Overall our study supports the use of therapeutic plasma exchange in COVID-19 patients. However, although statistically insignificant, there appears to be a higher mortality rate in patients with diabetes who received therapeutic plasma exchange in addition to standard therapy. As such, we recommend further investigation of this aspect.

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Published
2021-10-31
How to Cite
Arshad, K., ., Z.- e-H., Kamran, S., Khaliq, I., Asif, M., & Tanveer, S. (2021). THE EFFICACY OF PLASMA EXCHANGE IN COVID-19 PATIENTS WITH COMORBID DIABETES MELLITUS. PAFMJ, 71(5), 1732-35. https://doi.org/10.51253/pafmj.v71i5.6317
Section
Original Articles