Survival Outcomes in the Patients of Ovarian Epithelial Carcinomas Treated with Fertility-Sparing Surgery: A Study from a Developing Country

  • Musa Azhar Shaukat Khanum Memorial Cancer Hospital & Research Center, Lahore Pakistan
  • Shafquat Ali Khan Shaukat Khanum Memorial Cancer Hospital & Research Center, Lahore Pakistan
  • Syed Abdul Manan Hamdani Shaukat Khanum Memorial Cancer Hospital & Research Center, Lahore Pakistan
  • Tahira Yasmeen Shaukat Khanum Memorial Cancer Hospital & Research Center, Lahore Pakistan
  • Samia Yasmeen Shaukat Khanum Memorial Cancer Hospital & Research Center, Lahore Pakistan
  • Umme-e-Kalsoom Awan Shaukat Khanum Memorial Cancer Hospital & Research Center, Lahore Pakistan
  • Aamir Ali Syed Shaukat Khanum Memorial Cancer Hospital & Research Center, Lahore Pakistan
  • Neelam Siddiqui Shaukat Khanum Memorial Cancer Hospital & Research Center, Lahore Pakistan
Keywords: Carcinoma, Fertility sparing surgery, Ovarian epithelial, Ovarian neoplasms, Pregnancy

Abstract

Objective: To assess the outcomes of fertility-sparing surgery in patients with ovarian epithelial carcinoma treated at our centre.

Study Design: Retrospective longitudinal study.

Place and Duration of Study: Shaukat Khanum Memorial Cancer Hospital & Research Center, Lahore Pakistan, from Jul 2001 to Aug 2015.

Methodology: We studied 31 patients with ovarian epithelial carcinoma who underwent fertility-sparing surgery at Shaukat Khanum Memorial Hospital. The detail regarding patients and tumour characteristics, along with outcomes of the intervention, was obtained from secondary data kept in the electronic hospital information system.

Results: A total of 132 patients with ovarian epithelial carcinoma were identified; 31 patients underwent fertility-sparing surgery (Stage-IA, n=19; Stage-IC, n=12). By histopathology, 14(45.0%) had mucinous cystadenocarcinoma, 7(22.6%) serous adenocarcinoma, 6(19.4%) endometroid, and 4(12.9%) with clear cell pathology. The mean duration of follow-up was 52.6±2.3 months (18-118 months) after fertility-sparing surgery. Five-year recurrence-free survival was 81.0%. (Three-year=89.0%), using the Kaplan-Meier graph. Three patients had successful pregnancies, with one having a twin pregnancy.

Conclusion: Fertility-sparing surgery should be considered for children of early-stage epithelial ovarian carcinoma patients as it preserves fertility and endocrine function while avoiding recurrence.

Downloads

Download data is not yet available.
Published
2022-11-03
How to Cite
Azhar, M., Khan, S., Hamdani, S. A., Yasmeen, T., Yasmeen, S., Awan, U.- e-K., Syed, A., & Siddiqui, N. (2022). Survival Outcomes in the Patients of Ovarian Epithelial Carcinomas Treated with Fertility-Sparing Surgery: A Study from a Developing Country. Pakistan Armed Forces Medical Journal, 72(5), 1597-1601. https://doi.org/10.51253/pafmj.v72i5.5218
Section
Original Articles

Most read articles by the same author(s)