EFFICACY OF FIRST AVAILABLE DIRECT-ACTING ANTIVIRAL AGENT IN TREATMENT OF CHRONIC HEPATITIS C; RESULTS FROM A SINGLE CENTRE IN PAKISTAN

  • Arif Qayyum Khan Combined Military Hospital Lahore/CMH Lahore Medical College and IOD/National University of Medical Sciences (NUMS) Pakistan
  • Hala Mansoor Combined Military Hospital Lahore/CMH Lahore Medical College and IOD/National University of Medical Sciences (NUMS) Pakistan
  • Javed Iqbal Raja Combined Military Hospital Lahore/CMH Lahore Medical College and IOD/National University of Medical Sciences (NUMS) Pakistan
  • Raja Yasser Shahbaz Combined Military Hospital Lahore/CMH Lahore Medical College and IOD/National University of Medical Sciences (NUMS) Pakistan
  • Samina Fida Combined Military Hospital Lahore/CMH Lahore Medical College and IOD/National University of Medical Sciences (NUMS) Pakistan
  • Muhammad Siddique Combined Military Hospital Lahore/CMH Lahore Medical College and IOD/National University of Medical Sciences (NUMS) Pakistan
Keywords: Hepatitis C virus (HCV), SVR 12

Abstract

Objective: To determine the efficacy of dual (sofosbuvir and ribavirin) and triple therapy (sofosbuvir ribavirinpegylated interferon) for treatment of hepatitis C.

Study Design: Comparative cross sectional study.

Place and Duration of Study: Department of Medicine, Combined Military Hospital, Lahore, from Nov 2014 to
Mar 2017.

Methodology: A total of 182 consecutive patients with age ≥18 years and positive HCV RNA by polymerase
chain reaction were included, while patients with haemoglobin of <10 g/dl, albumin <2 g/dl, platelet count
of <100/uL, creatinine clearance of <60 mL/min or liver disease caused by non-hepatitis C related causes were
excluded from study.

Results: Total 129 (70.8%) were treated with dual and 53 (29.1%) with triple therapy. Amongst patients with
genotype 3 (158/182), the overall sustained virological response at 12 weeks (SVR 12) was 94.4% in patients with
dual therapy while it was 97.3% with triple therapy. In non-cirrhotic patients it was 95% in treatment naïve and
100% in treatment experienced group. While in cirrhotic patients with genotype 3, SVR 12 with dual therapy was
83.3% (p=0.331) and 88.9% in treatment naïve and treatment experienced patients respectively, while it was 100% in both groups with triple therapy. SVR 12 for genotype 1 (21/182) was 100%, both for dual as well as for triple therapy. Haematological side effects dominated the clinical picture with 11.5% suffering from anaemia.

Conclusion: Both dual and triple therapy were effective in patients with hepatitis C with acceptable level of side
effects, genotype 3 being the most predominant genotype.

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Published
2020-12-16
How to Cite
Khan, A., Mansoor, H., Raja, J., Shahbaz, R., Fida, S., & Siddique, M. (2020). EFFICACY OF FIRST AVAILABLE DIRECT-ACTING ANTIVIRAL AGENT IN TREATMENT OF CHRONIC HEPATITIS C; RESULTS FROM A SINGLE CENTRE IN PAKISTAN. Pakistan Armed Forces Medical Journal, 70(6), 1885-91. https://doi.org/10.51253/pafmj.v70i6.3469
Section
Original Articles