A COMPARATIVE STUDY OF INSULIN RESISTANCE IN PATIENTS OF POLYCYSTIC OVARY SYNDROME

Insulin Resistance in Polycystic Ovary Syndrome

  • Amena Arif Army Medical College/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Palvasha Waheed Army Medical College/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Robina Anees Pakistan Naval Shifa Hafeez, Islamabad Pakistan
  • Amir Rashid Army Medical College/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Saleem Ahmed Khan Army Medical College/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
Keywords: Insulin resistance, Obesity, Polycystic ovary syndrome

Abstract

Objective: To assess the relationship between obesity and insulin resistance in polycystic ovary syndrome affected women.

Study Design: Cross sectional comparative study.

Place and Duration of Study: Multidisciplinary Lab-I of Department of Biochemistry, Army Medical College, Rawalpindi, in collaboration with Pakistan Naval Ship Hafeez Hospital, Islamabad from Feb 2018 to Jan 2019.

Methodology: One hundred and five selected females (puberty till 25 years of age) were divided into three groups of 35 each. Blood samples were collected an overnight fast (from 8-11 AM). Serum level of insulin was measured and insulin resistance was calculated based on HOMA-IR.

Results: HOMA-IR concentrations correlated directly with Basal Metabolic Index, fasting plasma glucose and serum insulin levels. Mean serum insulin level was also elevated in patients with polycystic ovary syndrome (normal weight & overweight) as compared to control subjects (7.4 ± 1.2 mIU/L & 9.1 ± 0.8 mIU/L vs 6.3 ± 1.1 mIU/L; p as 0.003). The insulin resistance was slightly higher in patients with polycystic ovary syndrome as compared to the control subjects (1.4 ± 0.3 & 1.7 ± 0.2 vs. 1.1 ± 0.3; p<0.001).

Conclusion: HOMA-IR levels are positively associated with BMI, the intensity of peripheral insulin resistance in polycystic ovary syndrome-affected females, indicating that normal weight, and overweight patients with polycystic ovary syndrome have tendency towards insulin resistance.

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Published
2021-10-31
How to Cite
Arif, A., Waheed, P., Anees, R., Rashid, A., & Khan, S. (2021). A COMPARATIVE STUDY OF INSULIN RESISTANCE IN PATIENTS OF POLYCYSTIC OVARY SYNDROME. PAFMJ, 71(5), 1746-50. https://doi.org/10.51253/pafmj.v71i5.2633
Section
Original Articles

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