COMPARISON OF SOLIFENACIN VERSUS COMBINATION OF SOLIFENACIN AND TAMSULOSIN IN IMPROVING UNILATERAL DOUBLE-J STENT RELATED LOWER URINARY TRACT SYMPTOMS - A PROSPECTIVE RANDOMIZED CONTROL TRIAL

  • Muhammad Tanveer Sajid Armed Forces Institute of Urology/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Sami Ur Rehman Armed Forces Institute of Urology/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Muhammad Akmal Armed Forces Institute of Urology/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Hussain Ahmad Armed Forces Institute of Urology/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Zahoor Iqbal Mirza Armed Forces Institute of Urology/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Arshad Mahmood Armed Forces Institute of Urology/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
Keywords: LUTS, solifenacin, Ureteric stent-related symptoms, tamsulosin, IPSS

Abstract

Objective: To compare Solifenacin versus solifenacin plus tamsulosin in terms of international prostate symptom score (IPSS) for lower urinary tract symptoms (LUTS) in patients with unilateral double-J (DJ) ureteric stents.

Study Design: Comparative cross sectional study.

Place and Duration of Study: Armed Forces Institute of Urology, Rawalpindi from Sep 2018 to Feb 2019.

Methodology: A total of two hundred (n=200) patients of either gender aged 20-50 years, who underwent
unilateral DJ stenting for different endourological procedures, were enrolled after satisfying inclusion/exclusion
criteria and then randomly allocated to group A (Solifenacin 5mg once daily (OD) ± placebo for 2 weeks) or group B (Solifenacin 5mg OD ± Tamsulosin 0.4 mg OD for 2 weeks) respectively. Baseline (1st post-operative day) and Post 02 weeks treatment IPSS was recorded and analyzed.

Results: Mean age of presentation in group A and group B was 41.11 ± 6.45 vs 39.86 ± 5.34 years with p-value 0.14. Majority of patients in both groups were male (34% female in group A while 31% in group B, difference being statistically insignificant p 0.65). Baseline IPSS in group A and group B was 10.33 ± 2.72 vs 10.46 ± 3.12 with pvalue 0.76 (statistically insignificant) while post 02 weeks treatment IPSS in group A and B was 9.20 ± 2.67 vs 7.88 ± 2.63 respectively with p-value <0.001, the difference being statistically significant.

Conclusions: Current study revealed significant advantage of combination therapy (solifenacin ± tamsulosin)
compared with solifenacin monotherapy in lowering LUTS based on IPSS in patients having unilateral......

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Published
2021-02-23
How to Cite
Sajid, M., Rehman, S., Akmal, M., Ahmad, H., Mirza, Z., & Mahmood, A. (2021). COMPARISON OF SOLIFENACIN VERSUS COMBINATION OF SOLIFENACIN AND TAMSULOSIN IN IMPROVING UNILATERAL DOUBLE-J STENT RELATED LOWER URINARY TRACT SYMPTOMS - A PROSPECTIVE RANDOMIZED CONTROL TRIAL. PAFMJ, 71(1), 45-50. https://doi.org/10.51253/pafmj.v71i1.2617
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Original Articles

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