OSTEOMALACIA DUE TO TYPE-I RENAL TUBULAR ACIDOSIS IN A MIDDLE AGED PAKISTANI WOMAN

Osteomalacia due to type-I Renal Tubular Acidosis

Abstract

Osteomalacia, one of the causes of reduced bone density, is a disorder of mineralization of newly formed bone matrix in adults. Though it is an uncommon disease in western world, but it is not that infrequent in Indian subcontinent. Though dietary deficiency of vitamin-D is responsible for the vast majority of osteomalacia cases worldwide, but renal diseases can lead to osteomalacia in variety of ways including reduced formation of calcitriol, renal tubular acidosis (RTA) and secondary hyperparathyroidism. Among RTAs, it is seen most often with proximal RTA (type-II) and occasionally with distal RTA (type-I). We report a case of osteomalacia in a middle age Pakistani woman with type-I RTA and tubular interstitial nephritis (TIN) that appear to be induced by streptomycin