Clinical Presentation, Tumour Characteristics, Sociodemographic, And Lifestyle-Related Factors of Oral Cancer In Patients Visiting Abbasi Shaheed Hospital, Karachi Pakistan
DOI:
https://doi.org/10.51253/pafmj.v74i2.8172Keywords:
Oral cancer, mouth, Smoking, Squamous cell carcinoma, TobaccoAbstract
Objective: To determine the sociodemographic and lifestyle-related factors of oral cancer, clinical presentation, and tumour characteristics among patients visiting Abbasi Shaheed Hospital in Karachi, Pakistan.
Study Design: Cross-sectional study
Place and duration of study: Department of Oral and Maxillofacial Surgery, Abbasi Shaheed Hospital, Karachi Pakistan, from Oct 2020 to Nov 2021.
Methodology: One hundred and thirty-eight cases of diagnosed oral cancer were enrolled in the study and information wascollected regarding sociodemographic and lifestyle-related factors. Clinical presentation at the time of oral cancer diagnosiswas also recorded.
Results: The mean age of the patients was 48.59+14.28 years. Out of 138 cases, most were males 108(78.3%), most belonging toa low socioeconomic status 122(88.4%). 78(56.5%) of patients had well-differentiated squamous cell carcinoma, followed bymoderately differentiated 59(42.8%), and only 1(0.7%) had poorly differentiated oral cancer. The study showed that oral cancer was highest among people from low socioeconomic status, with well-differentiated squamous cell carcinoma being the most common type. Male gender, the use of chewable tobacco, and areca nuts were also reported as risk factors for oral cancer.
Conclusion: The study showed that oral cancer was highest among males and people belonging to low SES. Most of the cases had well-differentiated carcinoma and had a history of current and past use of tobacco, alcohol, and areca nut. Squamous cell carcinoma was the most common oral cancer.We need mass campaigns to raise awareness ..
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References
Petersen PE. Oral cancer prevention and control--the approach
of the World Health Organization. Oral Oncol 2009 ; 45(4-5):
-460.
https://doi.org/10.1016/j.oraloncology.2008.05.023
Conway DI, Purkayastha M, Chestnutt IG. The changing
epidemiology of oral cancer: definitions, trends, and risk
factors. Br Dent J 2018; 225(9): 867-873.
https://doi.org/10.1038/sj.bdj.2018.922
Moore SR, Johnson NW, Pierce AM, Wilson DF. The
epidemiology of mouth cancer: a review of global incidence.
Oral Dis 2000; 6(2): 65-74.
https://doi.org/10.1111/j.1601-0825.2000.tb00104.x
Ng JH, Iyer NG, Tan MH, Edgren G. Changing epidemiology
of oral squamous cell carcinoma of the tongue: A global study.
Head Neck 2017; 39(2): 297-304.
https://doi.org/10.1002/hed.24589
Ren ZH, Hu CY, He HR, Li YJ, Lyu J. Global and regional
burdens of oral cancer from 1990 to 2017: Results from the
global burden of disease study. Cancer Commun 2020; 40(2-3):
-92. https://doi.org/10.1002/cac2.12009
Bhurgri Y, Bhurgri A, Hussainy AS, Usman A, Faridi N, Malik
J, et al. Cancer of the oral cavity and pharynx in Karachi--
identification of potential risk factors. Asian Pac J Cancer Prev
; 4(2): 125-130.
Sohaib M. Pakistan Atomic Energy Commission Report
Nuclear Medicine & Oncology Division Pakistan Atomic
Energy Commission, Headquarter, Islamabad, Pakistan:
Atomic Energy Cancer Hospitals; 2019.
Babu KG. Oral cancers in India. Semin Oncol 2001; 28(2): 169-
https://doi.org/10.1016/s0093-7754(01)90088-0
Alqahtani WS, Almufareh NA, Al-Johani HA, Alotaibi RK,
Juliana CI, Aljarba NH, et al. Oral and Oropharyngeal Cancers
and Possible Risk Factors Across Gulf Cooperation Council
Countries: A Systematic Review. World J Oncol 2020; 11(4):
-181. https://doi.org/10.14740/wjon1283
Azhar N, Sohail M, Ahmad F, Fareeha S, Jamil S, Mughal N, et
al. Risk factors of Oral cancer- A hospital based case control
study. J Clin Exp Dent 2018; 10(4): e396-e401.
https://doi.org/10.4317%2Fjced.54618
Akhtar A, Hussain I, Talha M, Shakeel M, Faisal M, Ameen M,
et al. Prevalence and diagnostic of head and neck cancer in
Pakistan. Pak J Pharm Sci 2016; 29(5 Suppl): 1839-1846.
Badar F, Mahmood S. Hospital-based cancer profile at the
Shaukat Khanum Memorial Cancer Hospital and Research
Centre, Lahore, pakistan. J Coll Physicians Surg Pak 2015;
(4): 259-263.
Coelho KR. Challenges of the oral cancer burden in India. J
Cancer Epidemiol 2012; 2012: 701932.
https://doi.org/10.1155/2012/701932.
Amarasinghe A, Usgodaarachchi US, Johnson NW,
Warnakulasuriya S. High Prevalence of Lifestyle Factors
Attributable for Oral Cancer, and of Oral Potentially Malignant
Disorders in Rural Sri Lanka. Asian Pac J Cancer Prev 2018;
(9): 2485-2492.
https://doi.org/10.22034/apjcp.2018.19.9.2485.
Al-Jamaei AAH, van Dijk BAC, Helder MN, Forouzanfar T,
Leemans CR, de Visscher J. A population-based study of the
epidemiology of oral squamous cell carcinoma in the
Netherlands 1989-2018, with emphasis on young adults. Int J
Oral Maxillofac Surg 2022; 51(1): 18-26.
https://doi.org/10.1016/j.ijom.2021.03.006
Bhurgri Y. Cancer of the oral cavity - trends in Karachi South
(1995-2002). Asian Pac J Cancer Prev 2005; 6(1): 22-26.
Qureshi MA, Syed SA, Sharafat S. Lip and oral cavity cancers
(C00-C06) from a mega city of Pakistan: Ten-year data from the
Dow Cancer Registry. J Taibah Univ Med Sci 2021; 16(4): 624-
https://doi.org/10.1016/j.jtumed.2021.02.001
Azimi S, Rafieian N, Manifar S, Ghorbani Z, Tennant M,
Kruger E. Socioeconomic determinants as risk factors for
squamous cell carcinoma of the head and neck: a case-control
study in Iran. Br J Oral Maxillofac Surg 2018; 56(4): 304-309.
https://doi.org/10.1016/j.bjoms.2018.02.014.
Auluck A, Hislop G, Bajdik C, Hay J, Bottorff JL, Zhang L, et al.
Gender- and ethnicity-specific survival trends of oral cavity
and oropharyngeal cancers in British Columbia. Cancer Causes
Control 2012; 23(12): 1899-909.
https://doi.org/10.1007/s10552-012-0065-0
Khan Z, Suliankatchi RA, Heise TL, Dreger S. Naswar
(Smokeless Tobacco) Use and the Risk of Oral Cancer in
Pakistan: A Systematic Review With Meta-Analysis. Nicotine
Tob Res 2019; 21(1): 32-40. https://doi.org/10.1093/ntr/ntx281
Gupta B, Bray F, Kumar N, Johnson NW. Associations between
oral hygiene habits, diet, tobacco and alcohol and risk of oral
cancer: A case-control study from India. Cancer Epidemiol
; 51: 7-14. https://doi.org/10.1016/j.canep.2017.09.003
Mehrotra R, Pandya S, Chaudhary AK, Kumar M, Singh M.
Prevalence of oral pre-malignant and malignant lesions at a
tertiary level hospital in Allahabad, India. Asian Pac J Cancer
Prev 2008; 9(2): 263-265
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