The role of Tranexamic acid in the Reduction of Bleeding in Abdominal Aortic Aneurysm Surgery

Khan Muhammad Yaqub; Muhammad Saeed; Bilal Yasin; Khalid Ameer; Nusrat Noor

doi:10.51253/pafmj.v73i6.7689

Authors

Khan Muhammad Yaqub Department of Anesthesia, Combined Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
Muhammad Saeed Department of Anesthesia, Combined Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
Bilal Yasin Department of Anesthesia, Combined Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
Khalid Ameer Department of Anesthesia, Combined Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
Nusrat Noor Department of Anesthesia, Combined Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan

DOI:

https://doi.org/10.51253/pafmj.v73i6.7689

Keywords:

Aneurysm, Bleeding, Blood transfusion, Fibrin

Abstract

Objective: To determine the effects of Tranexamic acid on intraoperative blood loss.

Study Design: Quasi-experimental study.

Place and Duration of Study: Combined Military Hospital, Rawalpindi Pakistan, from Jun to Oct 2021.

Methodology: A total of 96 patients from both genders undergoing elective open abdominal aortic aneurysm surgery under general anaesthesia enrolled in the study after random distribution to Drug and Control Groups. The primary determinant was intraoperative blood loss. Additionally, determining variables were intraoperative and postoperative blood transfusions, thromboembolic episodes, and postoperative mortality rate.

Results: A total of 96 patients enrolled in the study, out of which 90(93%) were males, whereas 6(7%) were females, with a
mean age of 65.37±7.01 (55–75 years). Of 96 participants, 52(54%) patients were from ASA Class II and 44(46%) were from ASA Class III. There was no significant correlation between surgical time (p-value 0.45), clamping time (p-value 0.34), and
intraoperative and postoperative transfusions (p-value 0.56 and 0.28, respectively). However, a statistically significant
reduction in intraoperative and postoperative blood loss was recorded (p-value <0.001).

Conclusion: Tranexamic acid significantly impacts the reduction of intraoperative and postoperative bleeding in elective open abdominal aortic aneurysm surgeries under general anaesthesia.

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