The role of Tranexamic acid in the Reduction of Bleeding in Abdominal Aortic Aneurysm Surgery

Authors

  • Khan Muhammad Yaqub Department of Anesthesia, Combined Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Muhammad Saeed Department of Anesthesia, Combined Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Bilal Yasin Department of Anesthesia, Combined Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Khalid Ameer Department of Anesthesia, Combined Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan
  • Nusrat Noor Department of Anesthesia, Combined Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan

DOI:

https://doi.org/10.51253/pafmj.v73i6.7689

Keywords:

Aneurysm, Bleeding, Blood transfusion, Fibrin

Abstract

Objective: To determine the effects of Tranexamic acid on intraoperative blood loss.

Study Design: Quasi-experimental study.

Place and Duration of Study: Combined Military Hospital, Rawalpindi Pakistan, from Jun to Oct 2021.

Methodology: A total of 96 patients from both genders undergoing elective open abdominal aortic aneurysm surgery under general anaesthesia enrolled in the study after random distribution to Drug and Control Groups. The primary determinant was intraoperative blood loss. Additionally, determining variables were intraoperative and postoperative blood transfusions, thromboembolic episodes, and postoperative mortality rate.

Results: A total of 96 patients enrolled in the study, out of which 90(93%) were males, whereas 6(7%) were females, with a
mean age of 65.37±7.01 (55–75 years). Of 96 participants, 52(54%) patients were from ASA Class II and 44(46%) were from ASA Class III. There was no significant correlation between surgical time (p-value 0.45), clamping time (p-value 0.34), and
intraoperative and postoperative transfusions (p-value 0.56 and 0.28, respectively). However, a statistically significant
reduction in intraoperative and postoperative blood loss was recorded (p-value <0.001).

Conclusion: Tranexamic acid significantly impacts the reduction of intraoperative and postoperative bleeding in elective open abdominal aortic aneurysm surgeries under general anaesthesia.

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Published

30-12-2023

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Original Articles

How to Cite

1.
Yaqub KM, Saeed M, Yasin B, Ameer K, Noor N. The role of Tranexamic acid in the Reduction of Bleeding in Abdominal Aortic Aneurysm Surgery. Pak Armed Forces Med J [Internet]. 2023 Dec. 30 [cited 2024 Jul. 19];73(6):1679-82. Available from: https://pafmj.org/PAFMJ/article/view/7689