Drug-Induced Hand-Foot Syndrome in Cancer Patients Receiving Capecitabine in A Tertiary Care Hospital

Authors

  • Ibtisam Idrees Combined Military Hospital/National University of Medical Science(NUMS)Rawalpindi Pakistan
  • Riaz Ahmad Combined Military Hospital/National University of Medical Science(NUMS)Rawalpindi Pakistan
  • Muhammad Umair Combined Military Hospital/National University of Medical Science(NUMS)Rawalpindi Pakistan
  • Anum Zargham Fauji Foundation Hospital Rawalpindi Pakistan
  • Mir Jalal-ud- Din Woman Medical College Abbottabad Pakistan
  • Tahir Manoor Lone Combined Military Hospital/National University of Medical Science(NUMS)Rawalpindi Pakistan

DOI:

https://doi.org/10.51253/pafmj.v73i1.6786

Keywords:

Capecitabine, Cancer, Hand and foot syndrome

Abstract

Objective: To determine the frequency of hand-foot syndrome and associated factors among patients receiving Capecitabine for the management of cancer in a tertiary care setting.

Study Design: Cross-sectional study.

Place and Duration of Study: Oncology Department Combined Military Hospital, Rawalpindi Pakistan from Dec 2020 to May2021.

Methodology: One hundred patients with malignant conditions taking Capecitabine for more than two weeks were included in the study. A detailed relevant dermatological examination was carried out on all the patients to diagnose hand-foot syndrome based on the National Cancer Institute Common Terminology Criteria for Adverse Events Version 4.0 Grading of Hand-Foot Syndrome.

Results: Out of 100 cancer patients using Capecitabine for more than two weeks included in the study. Sixty-eight showed the presence of hand-foot syndrome, while 32 did not show any features of hand-foot syndrome. Combination treatment was statistically significantly associated with hand-foot syndrome among the patients included in our study (p-value<0.001).

Conclusion: Hand-foot syndrome was a common side effect seen in patients managed with Capecitabine for their cancerous condition. Patients using other chemotherapeutic agents along with Capecitabine were more at risk of having hand-foot syndrome than those taking Capecitabine alone.

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Published

22-02-2023

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Section

Original Articles

How to Cite

1.
Idrees I, Ahmad R, Umair M, Zargham A, Din MJ- ud-, Lone TM. Drug-Induced Hand-Foot Syndrome in Cancer Patients Receiving Capecitabine in A Tertiary Care Hospital. Pak Armed Forces Med J [Internet]. 2023 Feb. 22 [cited 2024 Oct. 7];73(1):70-3. Available from: https://pafmj.org/PAFMJ/article/view/6786