EFFECTS OF LOW VOLUME VENTILATION DURING CARDIOPULMONARY BYPASS ON POSTOPERATIVE PULMONARY OUTCOME AFTER CORONARY ARTERY BYPASS GRAFTING

Abstract

Objective: To study the effects of low volume ventilation during cardiopulmonary bypass on postoperative
pulmonary outcomes after coronary artery bypass grafting.
Study Design:Randomized controlled trial.
Place andDuration of Study: Army cardiac Centre CMH Lahorefor durationof 6 months from Apr to Sep 2016
Material and Methods:After taking approval by the hospital ethics committee which written informed consent,
was taken by 100 consecutive patients of either sex, undergoing CABG on CPB, were randomly divided into two
groups. Patients in Group I received continuous low volume ventilation (2ml/Kg) throughout the CPB period,
whereas ventilation was switched off and disconnected in patients of Group II.Frequency of post-operative
respiratory complications, duration of mechanical ventilation after surgery and intensive care unit (ICU) length of
stay (LOS) were noted in both groups.
Results:Whereas the demographics of both groups werealmost the same, patients in Group IIhad a significantly
longer post-operative mechanical ventilation time (4.68 vs 2.8 hrs,)with p-value(p=0.031); longer ICU LOS (1.84 vs
1.28 days, p=0.016) and more requirement of oxygen (O2) therapy (p=0.01); and had significant difference in postoperative pulmonary complications.
Conclusions:Our study reports that continued low tidal volume ventilation during CPB improved post-bypass
oxygenation and lung mechanics.